Articles with the topic: animal-model

Could molecular handcuffs lower the protein that causes Huntington's disease?

Could molecular handcuffs lower the protein that causes Huntington's disease?

Researchers got surprisingly lucky when looking for drug molecules to pull mutant huntingtin protein into a cellular garbage disposal machine

Dr Tamara MaiuriNovember 12, 2019

Exciting new Huntingtin lowering tool described

Exciting new Huntingtin lowering tool described

Exciting new Huntingtin Lowering work from @SangamoTx and @CHDIfoundation using "Zinc Fingers" to shut down expression of the mutant Huntingtin gene. More details on this exciting new technique here.

Dr Jeff CarrollAugust 05, 2019

Huntington's disease therapeutics conference 2019 - Day 2

Huntington's disease therapeutics conference 2019 - Day 2

New tools to bridge the gap between the lab and patients in our update from day 2 of the 2019 HD Therapeutics conference

Joel Stanton and Dr Jeff CarrollFebruary 28, 2019

Advances on many fronts in the battle against the protein that causes Huntington's disease

Advances on many fronts in the battle against the protein that causes Huntington's disease

This fall sees exciting announcements from a number of companies focused on novel Huntingtin Lowering technologies, including Wave, PTC and Voyager

Dr Jeff CarrollDecember 04, 2018

First Dolly, now Piglet; a new Huntington’s disease pig knock-in model confirmed

First Dolly, now Piglet; a new Huntington’s disease pig knock-in model confirmed

For the first time in HD research, an animal model has been created in pigs using 2 cutting edge DNA editing t

Caroline CaseyJuly 10, 2018

New roles for huntingtin: removing a healthy protein to understand its function

New roles for huntingtin: removing a healthy protein to understand its function

Completely removing normal huntingtin in adults may disrupt healthy brain function, a recent study suggests.

Leora FoxSeptember 26, 2017

Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)

Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)

Media reports of a wonder drug for neurodegenerative diseases like Huntington's disease are overhyped

Dr Michael FlowerMay 07, 2017

Enemy at the gates – huntingtin disrupts nuclear transport

Enemy at the gates – huntingtin disrupts nuclear transport

Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.

Tom PeskettApril 21, 2017

Sheep leading the flock: metabolism and biomarkers in HD

Sheep leading the flock: metabolism and biomarkers in HD

Sheep can help us to identify HD biomarkers and recognize metabolic changes that occur before symptoms develop.

Leora FoxMarch 27, 2017