Latest news

Making babies: having a family, the HD way

Making babies: having a family, the HD way

Making babies: HDBuzz's feature article - updated for 2024 - on fertility technologies that can help at-risk people to have HD-free children

Betony Childs and Dr Nayana LahiriJanuary 11, 2024

Steady progress from uniQure - promising data to end the year

Steady progress from uniQure - promising data to end the year

uniQure ushered in the end of the year by releasing some promising data from their huntingtin-lowering gene therapy trials

Dr Rachel HardingDecember 20, 2023

Putting it in print: GENERATION HD1 study results published

Putting it in print: GENERATION HD1 study results published

Data from GENERATION HD1, the Phase 3 clinical trial testing the huntingtin-lowering drug tominersen, have just been published in a scientific journal. The trial ended a while back, so why is this an important milestone, and what’s next?

Dr Sarah Hernandez, Dr Rachel Harding, and Dr Leora FoxDecember 07, 2023

Regulating repetition: Gaining control of CAG repeats could slow progression of Huntington’s disease

Regulating repetition: Gaining control of CAG repeats could slow progression of Huntington’s disease

Many diseases are caused by repetitive DNA sequences. Understanding the regulation of those repetitive sequences may hold the key for unlocking therapeutics for Huntington’s disease. A team from Toronto has just advanced our understanding.

Dr Jeff CarrollNovember 30, 2023

Beyond huntingtin lowering: out-of-the-box approaches for the treatment of HD

Beyond huntingtin lowering: out-of-the-box approaches for the treatment of HD

The HD pipeline is rich and varied. Let's talk about some out-of-the-box approaches for developing drugs for HD that don't involve huntingtin lowering.

Kelly AndrewNovember 24, 2023

Getting to the Root of Huntington's Disease: A Plant-Based Approach

Getting to the Root of Huntington's Disease: A Plant-Based Approach

Researchers used plants to study how to stop the Huntington’s disease protein from forming toxic clumps

Dr Rachel HardingOctober 15, 2023

Could halting CAG expansions be a new treatment for HD?

Could halting CAG expansions be a new treatment for HD?

The gene MSH3 is getting a lot of attention in HD research lately. New findings suggest MSH3 lowering could halt CAG repeat expansions, offering a new therapeutic avenue.

Dr Sarah HernandezOctober 05, 2023

Tipping the balance; new insights into HD genetic modifiers

Tipping the balance; new insights into HD genetic modifiers

A new study from researchers at Thomas Jefferson University delves into the details of how genetic modifiers of Huntington’s disease work.

Dr Rachel HardingSeptember 01, 2023

Drug to treat movement symptoms of HD approved by FDA

Drug to treat movement symptoms of HD approved by FDA

The FDA has approved valbenazine, also known as INGREZZA, as a treatment for the movement symptoms of Huntington’s disease

Dr Leora Fox and Dr Rachel HardingAugust 22, 2023

Youthful competitors: young brain cells oust the old

Youthful competitors: young brain cells oust the old

Replacing cells with HD in the brain could be an effective treatment strategy. Recent work shows that glia injected into mouse brains take over and oust the older cells, but for a surprising reason - because of age, not HD!

Dr Sarah HernandezAugust 08, 2023

Updates from PTC Therapeutics and uniQure on their huntingtin-lowering trials

Updates from PTC Therapeutics and uniQure on their huntingtin-lowering trials

Both PTC Therapeutics and uniQure have shared updates from their respective clinical trials, testing different huntingtin-lowering approaches. We explore the data presented from both of these studies and what this means for HD family members.

Dr Leora Fox and Dr Rachel HardingJune 21, 2023