Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Latest news

New collaboration seeks to speed Huntington's disease drug licensing

New collaboration seeks to speed Huntington's disease drug licensing

Dr Jeff Carroll on May 10, 2018

Recently the Critical Path Institute announced a new effort - the Huntington's Disease Regulatory Science Consortium, or HD-RSC. This collaboration with many international partners aims to speed the development of new HD treatments. What's all this about, and how could it help HD patients?

HDSA’s Q&A on the latest huntingtin-lowering update from Ionis and Roche

HDSA’s Q&A on the latest huntingtin-lowering update from Ionis and Roche

Leora Fox on April 26, 2018

Earlier this week, Ionis Pharmaceuticals put out a press release after presenting data from the HTTRx (RG6042) Huntingtin-lowering clinical trial program at a scientific conference. Ionis’ partner Roche also released a community statement. Our friend at Huntington’s Disease Society of America, Dr Leora Fox, has prepared this Q&A in response to community questions received after the release. We liked it so much, we decided to reproduce it here, by kind permission, for the benefit of HDBuzz readers.

Exciting Experiments in "Open Science" by Huntington's Researchers

Exciting Experiments in "Open Science" by Huntington's Researchers

Anna Marie Yanny on April 20, 2018

Drs Rachel Harding and Tam Maiuri are taking a leap of faith to make discoveries in Huntington’s Disease (HD) research swift and open to all. They are publishing their lab notes on fundamental HD research online in real time, at the risk of losing credit for their work. As a result, they hope to speed the path of discovery to more effective HD treatments.

The structure of the protein that causes Huntington's disease, revealed

The structure of the protein that causes Huntington's disease, revealed

Caroline Casey on April 03, 2018

The cause of Huntington’s disease has been known since 1993, but the physical structure of the healthy huntingtin protein proved difficult to discover until now. German scientists have now revealed the shape of the huntingtin protein for the first time. Although the structure of the mutant form of the protein was not investigated, this study provides an excellent platform to build upon and will boost drug development efforts.

Huntington's disease therapeutics conference 2018 - day 3

Huntington's disease therapeutics conference 2018 - day 3

Dr Jeff Carroll on March 02, 2018

Good morning from the final day of the 2018 HD Therapeutics Conference! Two sessions today, the first focused on the protein made from the HD gene. The second includes updates on Huntingtin Lowering Trials from both Wave Life Sciences and Ionis Pharmaceuticals.

Huntington's disease therapeutics conference 2018 - day 2

Huntington's disease therapeutics conference 2018 - day 2

Dr Jeff Carroll on March 01, 2018

Updates from day 2 of the Huntington's Disease Therapeutics Conference focusing on DNA repair in HD.

Huntington's disease therapeutics conference 2018 - day 1

Huntington's disease therapeutics conference 2018 - day 1

Dr Ed Wild on February 28, 2018

Jeff and Ed report from the Huntington's Disease Therapeutics Conference - the biggest annual gathering of HD researchers. This year's conference is bigger and more exciting than ever.

An early role for the Huntington's disease gene – but don't believe all the headlines

An early role for the Huntington's disease gene – but don't believe all the headlines

Dr Jeff Carroll on February 27, 2018

New hints are emerging about the normal role of the gene that causes Huntington's disease. A recent report uses cutting edge techniques to study this question in cells growing in the lab. We'll help separate the fascinating new science from some scary-sounding headlines.

New interest in an old target

New interest in an old target

Dr Jeff Carroll on January 30, 2018

A recent mouse study of a drug known as CTEP suggests the drug is surprisingly helpful for HD-like symptoms in mice. This is a welcome surprise, because it suggests a well-understood brain process might be a useful drug target for future HD research.