Articles with the topic: animal-model

Enemy at the gates – huntingtin disrupts nuclear transport

Enemy at the gates – huntingtin disrupts nuclear transport

Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.

Tom PeskettApril 21, 2017

Sheep leading the flock: metabolism and biomarkers in HD

Sheep leading the flock: metabolism and biomarkers in HD

Sheep can help us to identify HD biomarkers and recognize metabolic changes that occur before symptoms develop.

Dr Leora FoxMarch 27, 2017

Important advances in next generation genome editing tools for Huntington's Disease

Important advances in next generation genome editing tools for Huntington's Disease

Work with genome editing techniques (zinc fingers and CRISPR) brings these tools closer to use in HD clinical trials

Mr. Shawn MinnigOctober 31, 2016

Early exposure to the HD protein may cause life-long symptoms

Early exposure to the HD protein may cause life-long symptoms

A surprising new mouse study suggests the mutant HD gene may do some of its damage during embryonic development

Mr. Shawn MinnigJune 28, 2016

Harnessing the power of viruses to treat Huntington's disease

Harnessing the power of viruses to treat Huntington's disease

Researchers design a virus to more effectively deliver gene-silencing drugs throughout the brain.

Dr Leora FoxFebruary 03, 2016

A recycled drug gives us new insight in to HD

A recycled drug gives us new insight in to HD

An existing drug could give a boost to HD brain cells – but it may need more testing before it’s back in the clinic

Dr Leora FoxDecember 15, 2015

Novel research technique suggests an antioxidant gene protects vulnerable neurons

Novel research technique suggests an antioxidant gene protects vulnerable neurons

Researchers use a new technique in an HD mouse to uncover a gene, Gpx6, that is protective to vulnerable neurons.

Dr Leora FoxApril 06, 2015

Building a Better Mouse(trap): A New Model of Huntington’s Disease

Building a Better Mouse(trap): A New Model of Huntington’s Disease

New mouse model gives insights into Huntington's disease

Melissa ChristiansonMarch 16, 2015

Taking new targets to the bank: the DNA repair protein ‘ATM’ is overactive in Huntington's disease

Taking new targets to the bank: the DNA repair protein ‘ATM’ is overactive in Huntington's disease

HD causes the normally helpful protein "ATM" to get a little overzealous. Now we can look for drugs to settle it down

Terry Jo BichellMarch 09, 2015