Animal models of Huntington's disease: what they tell us about the disease and how can they help develop new therapie
Recent study in fruit flies identifies a new connection between synapses and HD
Work from multiple labs suggests activating a protein called SIRT1 might help HD, but the picture is still confusing
Bone marrow transplant protects HD mice from some symptoms, suggesting the immune system may be an important target
CBP, a gene-switching protein, protects memory in HD mice; 'histone deacetylase inhibitor' drug mimics its effects
Melatonin delays disease onset and extends survival in Huntington's disease mice – could it do the same for patients?
A drug that activates an ancient cellular defense mechanism slows down HD in mice – but why didn’t the benefit last?
Huntington's disease mice absorb less nutrition from food - which might help explain why human patients lose weight.
Huntington's disease mice are fat but HD patients lose weight – is a brain area called the hypothalamus to blame?