Articles with the topic: animal-model

Bone marrow transplantation in Huntington's Disease

Bone marrow transplantation in Huntington's Disease

Bone marrow transplant protects HD mice from some symptoms, suggesting the immune system may be an important target

Dr Tony HannanJanuary 04, 2012

HDAC inhibitor drug protects memory in HD mice

HDAC inhibitor drug protects memory in HD mice

CBP, a gene-switching protein, protects memory in HD mice; 'histone deacetylase inhibitor' drug mimics its effects

Dr Ed WildDecember 13, 2011

Melatonin treatment success in HD mice

Melatonin treatment success in HD mice

Melatonin delays disease onset and extends survival in Huntington's disease mice – could it do the same for patients?

Dr Ed WildOctober 31, 2011

Protein-folding drug helps HD mice... for a while

Protein-folding drug helps HD mice... for a while

A drug that activates an ancient cellular defense mechanism slows down HD in mice – but why didn’t the benefit last?

Dr Ed WildAugust 23, 2011

Not all in your head: digestive problems in HD

Not all in your head: digestive problems in HD

Huntington's disease mice absorb less nutrition from food - which might help explain why human patients lose weight.

Dr Jeff CarrollJune 18, 2011

Chubby mice reveal the importance of the hypothalamus in Huntington's disease

Chubby mice reveal the importance of the hypothalamus in Huntington's disease

Huntington's disease mice are fat but HD patients lose weight – is a brain area called the hypothalamus to blame?

Dr Ed WildMay 02, 2011

What do sheep brains have to do with HD?

What do sheep brains have to do with HD?

How smart are sheep, and why do HD researchers care?

Dr Jeff CarrollMarch 09, 2011

Anti-nausea drug helps cells with the HD mutation stay healthy in a surprising way

Anti-nausea drug helps cells with the HD mutation stay healthy in a surprising way

Anti-nausea drug meclizine protects cells with the HD mutation from death by reducing cellular energy production

Dr Jeff CarrollFebruary 04, 2011

Memantine in HD: dose is everything

Memantine in HD: dose is everything

Memantine, a drug already used in Alzheimer’s disease, might help in HD, but a mouse study shows dose is everything.

Dr Jeff CarrollJanuary 15, 2011