Articles with the topic: disease-modifying

ASO gene silencing reaches further, lasts longer

ASO gene silencing reaches further, lasts longer

Silencing the Huntingtin gene using ASO drugs reaches further, lasts longer and is safe. Human trial soon?

Dr Nayana LahiriJune 21, 2012

Double success for huntingtin RNAi gene silencing

Double success for huntingtin RNAi gene silencing

2 bits of good news for RNAi gene silencing in HD: it's safe over six months, and a way to treat bigger brain areas

Dr Ed WildJanuary 24, 2012

New experiments clarify the role of SIRT1 in HD - or do they?

New experiments clarify the role of SIRT1 in HD - or do they?

Work from multiple labs suggests activating a protein called SIRT1 might help HD, but the picture is still confusing

Dr Jeff CarrollJanuary 12, 2012

Bone marrow transplantation in Huntington's Disease

Bone marrow transplantation in Huntington's Disease

Bone marrow transplant protects HD mice from some symptoms, suggesting the immune system may be an important target

Dr Tony HannanJanuary 04, 2012

Melatonin treatment success in HD mice

Melatonin treatment success in HD mice

Melatonin delays disease onset and extends survival in Huntington's disease mice – could it do the same for patients?

Dr Ed WildOctober 31, 2011

HDAC inhibitors and a possible 'blood biomarker'

HDAC inhibitors and a possible 'blood biomarker'

HDAC inhibitors explained, plus how new HDAC-related Huntington's disease research might help us find biomarkers

Dr Ed WildOctober 14, 2011

Gene silencing takes a targeted step forward

Gene silencing takes a targeted step forward

Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched

Dr Michael OrthOctober 07, 2011

Prana Biotech's new trial of PBT2 in Huntington's disease: the lowdown

Prana Biotech's new trial of PBT2 in Huntington's disease: the lowdown

Prana Biotech's PBT2 trial in Huntington's disease: what we know so far & what copper has to do with the mutant prote

Dr Ed WildOctober 03, 2011

Protein-folding drug helps HD mice... for a while

Protein-folding drug helps HD mice... for a while

A drug that activates an ancient cellular defense mechanism slows down HD in mice – but why didn’t the benefit last?

Dr Ed WildAugust 23, 2011