Silencing the Huntingtin gene using ASO drugs reaches further, lasts longer and is safe. Human trial soon?
2 bits of good news for RNAi gene silencing in HD: it's safe over six months, and a way to treat bigger brain areas
Work from multiple labs suggests activating a protein called SIRT1 might help HD, but the picture is still confusing
Bone marrow transplant protects HD mice from some symptoms, suggesting the immune system may be an important target
Melatonin delays disease onset and extends survival in Huntington's disease mice – could it do the same for patients?
HDAC inhibitors explained, plus how new HDAC-related Huntington's disease research might help us find biomarkers
Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched
Prana Biotech's PBT2 trial in Huntington's disease: what we know so far & what copper has to do with the mutant prote
A drug that activates an ancient cellular defense mechanism slows down HD in mice – but why didn’t the benefit last?