Articles with the topic: disease-modifying

HDAC inhibitors and a possible 'blood biomarker'

HDAC inhibitors and a possible 'blood biomarker'

HDAC inhibitors explained, plus how new HDAC-related Huntington's disease research might help us find biomarkers

Professor Ed WildOctober 14, 2011

Gene silencing takes a targeted step forward

Gene silencing takes a targeted step forward

Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched

Dr Michael OrthOctober 07, 2011

Prana Biotech's new trial of PBT2 in Huntington's disease: the lowdown

Prana Biotech's new trial of PBT2 in Huntington's disease: the lowdown

Prana Biotech's PBT2 trial in Huntington's disease: what we know so far & what copper has to do with the mutant prote

Professor Ed WildOctober 03, 2011

Protein-folding drug helps HD mice... for a while

Protein-folding drug helps HD mice... for a while

A drug that activates an ancient cellular defense mechanism slows down HD in mice – but why didn’t the benefit last?

Professor Ed WildAugust 23, 2011

Re-routing the huntingtin protein inside cells

Re-routing the huntingtin protein inside cells

Canadian team decodes the tags that re-route the huntingtin protein within cells, helping explain how it becomes toxi

Dr Jeff CarrollJune 26, 2011

KMO inhibitor drug improves lifespan of Huntington's disease mice

KMO inhibitor drug improves lifespan of Huntington's disease mice

Positive results from tests of a new 'KMO inhibiting' drug in Huntington's disease mice

Professor Ed WildJune 02, 2011

Gene silencing for HD: the story so far

Gene silencing for HD: the story so far

Is gene silencing as exciting as it sounds for HD, and what might the future hold?

Professor Ed WildMarch 22, 2011

Interview: Graeme Bilbe, Global Head for Neuroscience at Novartis

Interview: Graeme Bilbe, Global Head for Neuroscience at Novartis

HDBuzz interviews Graeme Bilbe, Global Head for Neuroscience at pharmaceutical giant Novartis, about their HD researc

Professor Ed WildMarch 14, 2011

CHDI Report: Day 3

CHDI Report: Day 3

Day 3 of CHDI’s HD therapeutics conference: growth factors and CHDI’s advanced therapies

Dr Jeff CarrollFebruary 10, 2011

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