Articles with the topic: gene-silencing

HDSA’s Q&A on the latest huntingtin-lowering update from Ionis and Roche

HDSA’s Q&A on the latest huntingtin-lowering update from Ionis and Roche

Our friends at @hdsa have produced this really good Q&A document about the latest huntingtin-lowering news.

Leora FoxApril 26, 2018

Huntington's disease therapeutics conference 2018 - day 3

Huntington's disease therapeutics conference 2018 - day 3

Updates from day 3 of the Huntington’s Disease Therapeutics Conference: huntingtin protein - and lowering it

Dr Jeff CarrollMarch 02, 2018

An early role for the Huntington's disease gene – but don't believe all the headlines

An early role for the Huntington's disease gene – but don't believe all the headlines

A surprising new paper sheds light on the role of the HD gene early in development. Should we worry?

Dr Jeff CarrollFebruary 27, 2018

Success! ASO drug reduces levels of mutant protein in Huntington's disease patients

Success! ASO drug reduces levels of mutant protein in Huntington's disease patients

Amazing news from Ionis and Roche! HTTRx drug successfully lowers harmful huntingtin protein in spinal fluid

Dr Jeff CarrollDecember 11, 2017

Update confirms Huntington's disease 'gene silencing' trial on track

Update confirms Huntington's disease 'gene silencing' trial on track

Ionis says its trial of HTTRx, intended to lower huntingtin protein, is fully recruited and plans to extend it

Dr Jeff CarrollOctober 15, 2017

New roles for huntingtin: removing a healthy protein to understand its function

New roles for huntingtin: removing a healthy protein to understand its function

Completely removing normal huntingtin in adults may disrupt healthy brain function, a recent study suggests.

Leora FoxSeptember 26, 2017

Precision huntingtin-lowering drug trials target the mutant protein

Precision huntingtin-lowering drug trials target the mutant protein

WAVE Life Sciences launches PRECISION clinical trial to suppress the mutant Huntington's disease protein

Dr Michael FlowerAugust 25, 2017

Huntington's Disease Therapeutics Conference 2017 - Day 2

Huntington's Disease Therapeutics Conference 2017 - Day 2

HDBuzz summarises all the science from the 2017 Huntington's Disease Therapeutics Conference in Malta - day 2

Dr Jeff CarrollApril 29, 2017

Important advances in next generation genome editing tools for Huntington's Disease

Important advances in next generation genome editing tools for Huntington's Disease

Work with genome editing techniques (zinc fingers and CRISPR) brings these tools closer to use in HD clinical trials

Mr. Shawn MinnigOctober 31, 2016