Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: gene-silencing

'Buzzilia' from the Huntington's Disease World Congress: day 4

'Buzzilia' from the Huntington's Disease World Congress: day 4

Dr Jeff Carroll on September 18, 2013

Our final report from the last morning of the World Congress on Huntington's Disease in Rio de Janeiro, Brazil.

Gene silencing drug safe in ALS patients... bring on Huntington's disease trials

Gene silencing drug safe in ALS patients... bring on Huntington's disease trials

Joseph Ochaba on June 29, 2013

Gene silencing drugs, which tell cells to stop making the harmful huntingtin protein, are among the top approaches being worked on to fight Huntington's disease. A human trial in motor neuron disease using 'ASO' gene silencing drugs has just shown the drugs and delivery method to be safe, boosting plans to get clinical trials of these drugs up and running in HD.

HD Therapeutics Conference 2013 Updates: Day 2

HD Therapeutics Conference 2013 Updates: Day 2

Dr Ed Wild on April 10, 2013

Our second daily report from the annual Huntington's Disease Therapeutics Conference in Venice, Italy. You can tweet @HDBuzzFeed, comment on Facebook or use HDBuzz.net to send us questions, comments and queries.

Major Roche-Isis deal boosts Huntington's disease gene silencing

Major Roche-Isis deal boosts Huntington's disease gene silencing

Dr Ed Wild on April 09, 2013

Isis Pharmaceuticals and Roche have announced a multi-million dollar deal to support the development of 'gene silencing' drugs to human trials. This is big news that secures the future of these exciting drugs for Huntington's disease.

Lost in translation? New insights into the making of the Huntington's disease protein

Lost in translation? New insights into the making of the Huntington's disease protein

Melissa Christianson on April 01, 2013

Everyone has two copies of the huntingtin gene but Huntington's disease is caused by a copy that's extra-long. New research shows that cells have different controls for how the normal and extra-long instructions are used to make protein. These controls on the protein-making process may be targets for developing drugs for HD.

Giving Huntington's disease the finger? Two teams report success for zinc-finger drugs in cells and mice

Giving Huntington's disease the finger? Two teams report success for zinc-finger drugs in cells and mice

Dr Ed Wild on November 01, 2012

Designing drugs that tell our cells to make less of the harmful mutant huntingtin protein is one of the most promising approaches to treating Huntington's disease. Most huntingtin-lowering attempts so far have tried to 'shoot the messenger' rather than attacking the source of the message - the DNA itself. Now, two independent reports of success in HD mice have given a boost to 'zinc finger' drugs - which interact directly with the HD gene itself. It's early days for this new technology: what do we know, and what challenges are ahead?

Interview: Alice and Nancy Wexler

Interview: Alice and Nancy Wexler

Dr Ed Wild on October 20, 2012

The Hereditary Disease Foundation, or HDF, is a key player in the world of Huntington's disease research. At the HDF's recent biennial scientific meeting in Cambridge, Massachusetts - 'The Milton Wexler Celebration of Life and Creativity' - HDBuzz met Nancy and Alice Wexler, the remarkable sisters at the heart of the HDF's work.

Video: What’s new in Huntington's disease research 2012

Video: What’s new in Huntington's disease research 2012

Dr Ed Wild on October 10, 2012

Watch the video of Ed Wild's address to the European Huntington's Association annual meeting in September 2012, summarizing how therapies research works and explaining the most exciting ways researchers are trying to study and treat HD.

Shooting the messenger with single-stranded RNA gene silencing

Shooting the messenger with single-stranded RNA gene silencing

Dr Nayana Lahiri on September 24, 2012

After huge leaps forward in recent years, we're edging ever closer to human trials of huntingtin lowering or 'gene silencing' as a potential treatment for Huntington’s Disease. Newer, better and safer techniques are always welcome and the announcement of ‘single-stranded RNA’ silencing is causing quite a hubbub. What’s it all about?