Articles with the topic: mouse-model

A step forward for gene editing: CRISPR-Cas9 and HD

A step forward for gene editing: CRISPR-Cas9 and HD

Evolving CRISPR-Cas9 techniques can now be used to edit the HD gene in a living mouse brain.

Leora FoxJuly 26, 2017

Enemy at the gates – huntingtin disrupts nuclear transport

Enemy at the gates – huntingtin disrupts nuclear transport

Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.

Tom PeskettApril 21, 2017

The benefits of migration, highlighted in Huntington's disease

The benefits of migration, highlighted in Huntington's disease

Is HD a developmental disease? HD stops neurons migrating in developing brain, but maybe we can get them going again

Dr Michael FlowerFebruary 10, 2017

Early exposure to the HD protein may cause life-long symptoms

Early exposure to the HD protein may cause life-long symptoms

A surprising new mouse study suggests the mutant HD gene may do some of its damage during embryonic development

Mr. Shawn MinnigJune 28, 2016

Huntingtin takes a trip: harmful proteins pass between brain cells

Huntingtin takes a trip: harmful proteins pass between brain cells

Harmful misfolded huntingtin can travel between brain cells via messenger particles called exosomes

Leora FoxJune 06, 2016

A recycled drug gives us new insight in to HD

A recycled drug gives us new insight in to HD

An existing drug could give a boost to HD brain cells – but it may need more testing before it’s back in the clinic

Leora FoxDecember 15, 2015

A multiple sclerosis drug that works for Huntington's disease: the real deal or too good to be true?

A multiple sclerosis drug that works for Huntington's disease: the real deal or too good to be true?

Fingolimod, a drug used in multiple sclerosis, prevents memory problems in HD mice. Would it work in patients?

Melissa ChristiansonNovember 24, 2015

New tool to measure outcomes in Huntington’s Disease clinical trials

New tool to measure outcomes in Huntington’s Disease clinical trials

A better tool for HD trials! New research shows innovative way to measure mutant Huntingtin outside the brain

Megan KrenchSeptember 03, 2015

A faulty filter? Blood vessel changes in Huntington's disease

A faulty filter? Blood vessel changes in Huntington's disease

New research reveals blood vessel changes that could contribute to problem in HD

Melissa ChristiansonMay 13, 2015