A Chinese research team developed a new way to lower huntingtin protein indirectly, by targeting a protein called GPR52. The molecules they designed were protective in cells and in mice with HD.
Scientists screen the ENTIRE genome to find new potential therapeutic targets for HD. This ambitious study provides a wealth of data for HD researchers
Researchers got surprisingly lucky when looking for drug molecules to pull mutant huntingtin protein into a cellular garbage disposal machine
Exciting new Huntingtin Lowering work from @SangamoTx and @CHDIfoundation using "Zinc Fingers" to shut down expression of the mutant Huntingtin gene. More details on this exciting new technique here.
Evolving CRISPR-Cas9 techniques can now be used to edit the HD gene in a living mouse brain.
Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.
Is HD a developmental disease? HD stops neurons migrating in developing brain, but maybe we can get them going again
A surprising new mouse study suggests the mutant HD gene may do some of its damage during embryonic development
Harmful misfolded huntingtin can travel between brain cells via messenger particles called exosomes