Articles with the topic: mouse-model

BAC to basics: a more accurate mouse model for Huntington's disease

BAC to basics: a more accurate mouse model for Huntington's disease

A genetically-tweaked Huntington's disease mouse model shows a tendency for the CAG repeat to grow, just like we see in humans with the mutation.

Dr Michael FlowerFebruary 10, 2022

Oral drug may change the story for huntingtin lowering

Oral drug may change the story for huntingtin lowering

Researchers with PTC Therapeutics recently published exciting new findings - a promising new huntingtin lowering drug that can be taken as a pill. Will this change how we move forward with huntingtin lowering?

Dr Sarah Hernandez and Dr Jeff CarrollFebruary 01, 2022

GPR52: Exploring a new way to lower huntingtin

GPR52: Exploring a new way to lower huntingtin

A Chinese research team developed a new way to lower huntingtin protein indirectly, by targeting a protein called GPR52. The molecules they designed were protective in cells and in mice with HD.

Dr Rachel HardingFebruary 11, 2021

Screening the entire genome for new drug targets for HD

Screening the entire genome for new drug targets for HD

Scientists screen the ENTIRE genome to find new potential therapeutic targets for HD. This ambitious study provides a wealth of data for HD researchers

Dr Rachel HardingFebruary 23, 2020

Could molecular handcuffs lower the protein that causes Huntington's disease?

Could molecular handcuffs lower the protein that causes Huntington's disease?

Researchers got surprisingly lucky when looking for drug molecules to pull mutant huntingtin protein into a cellular garbage disposal machine

Dr Tamara MaiuriNovember 12, 2019

Exciting new Huntingtin lowering tool described

Exciting new Huntingtin lowering tool described

Exciting new Huntingtin Lowering work from @SangamoTx and @CHDIfoundation using "Zinc Fingers" to shut down expression of the mutant Huntingtin gene. More details on this exciting new technique here.

Dr Jeff CarrollAugust 05, 2019

A step forward for gene editing: CRISPR-Cas9 and HD

A step forward for gene editing: CRISPR-Cas9 and HD

Evolving CRISPR-Cas9 techniques can now be used to edit the HD gene in a living mouse brain.

Dr Leora FoxJuly 26, 2017

Enemy at the gates – huntingtin disrupts nuclear transport

Enemy at the gates – huntingtin disrupts nuclear transport

Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.

Tom PeskettApril 21, 2017

The benefits of migration, highlighted in Huntington's disease

The benefits of migration, highlighted in Huntington's disease

Is HD a developmental disease? HD stops neurons migrating in developing brain, but maybe we can get them going again

Dr Michael FlowerFebruary 10, 2017