Articles with the topic: stem-cells

Mini brains grown in a dish shed light on Huntington’s disease and how we might treat it

Mini brains grown in a dish shed light on Huntington’s disease and how we might treat it

Exciting new findings using 3D human lab-grown mini brains inform ongoing HTT-lowering trials and suggest that stem cell transplants for HD may improve cell-to-cell communication and reduce disease features.

Dr Sarah HernandezAugust 23, 2024

The VIP section: velvet ropes for the brain and how to get in

The VIP section: velvet ropes for the brain and how to get in

New work from two groups advances tools to model the blood-brain barrier and could improve the way drugs are delivered for brain diseases. This builds on our ability to study, and eventually treat, Huntington’s disease.

Dr Sarah HernandezJune 10, 2024

Youthful competitors: young brain cells oust the old

Youthful competitors: young brain cells oust the old

Replacing cells with HD in the brain could be an effective treatment strategy. Recent work shows that glia injected into mouse brains take over and oust the older cells, but for a surprising reason - because of age, not HD!

Dr Sarah HernandezAugust 08, 2023

The third dimension: using minibrains to understand brain development changes in HD

The third dimension: using minibrains to understand brain development changes in HD

Researchers show that highly expanded CAGs in the HD gene can cause early developmental changes using 3D brain models called organoids. What’d they find?

Dr Sarah HernandezFebruary 06, 2020

Huntington's disease therapeutics conference 2018 - day 1

Huntington's disease therapeutics conference 2018 - day 1

Our daily roundup of the science presented at the 2018 HD Therapeutics Conference in Palm Springs

Professor Ed WildFebruary 28, 2018

Huntington's Disease Therapeutics Conference 2017 - Day 3

Huntington's Disease Therapeutics Conference 2017 - Day 3

HDBuzz summarises final day of the 2017 Huntington's Disease Therapeutics Conference in Malta

Professor Ed WildApril 30, 2017

Huntington's Disease Therapeutics Conference 2016 - day 3

Huntington's Disease Therapeutics Conference 2016 - day 3

Stem cells and modeling Huntington's disease in our final Therapeutics Conference report

Dr Jeff CarrollFebruary 28, 2016

Turning skin cells into brain cells: a Huntington's disease research breakthrough?

Turning skin cells into brain cells: a Huntington's disease research breakthrough?

Scientists can now change human skin cells into working neurons, like the ones that are most affected in HD.

Lakshini MendisNovember 27, 2014

Jumping genes: Huntington's disease protein invades brain transplants

Jumping genes: Huntington's disease protein invades brain transplants

A long-term study of the brains of HD patients who received grafts of fetal tissue reveals a surprising result

Dr Jeff CarrollMay 26, 2014

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