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Picking MSH3’s Pocket: New Insights into CAG Repeat Expansion
8 min read
Latest News
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What Pigs Revealed that Mice Missed in Huntington’s Disease
9 min read
A change in one gene can disrupt thousands of others in HD. A study in pigs suggests an explanation: expanded huntingtin interferes with chemical marks on DNA. The same effect wasn’t seen in mice, showing that the animal model matters.
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Going toe-to-toe with tau: new insights into the chemical basis of Huntington’s disease
6 min read
Does tau protein – which causes problems in other neurodegenerative diseases – contribute to Huntington's disease?
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New results bring BDNF therapies into focus
7 min read
Some unexpected findings suggest new ways to aim at an old target in HD
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2CARE study of coenzyme Q for Huntington's disease ends in disappointment
7 min read
The largest ever HD drug trial, testing coenzyme Q10, is halted for 'futility'. What does that mean for HD research?
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A starring role for astrocytes in Huntington's disease?
6 min read
Brain cells called astrocytes might play a bigger role than previously thought in Huntington's disease
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HD mice provide a useful failure
5 min read
Can drug trials that fail be helpful? A HD mouse study provides solid evidence of an approach that doesn't help HD
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Illuminating the progression of Huntington’s disease
6 min read
Researchers have used mice with glowing brain cells to decipher the first steps of neurodegeneration
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Jumping genes: Huntington's disease protein invades brain transplants
6 min read
A long-term study of the brains of HD patients who received grafts of fetal tissue reveals a surprising result
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The brain in Huntington's disease: greater than the sum of its parts?
6 min read
An important new study asks the question: what parts of the brain might need most help in HD?
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NUB1: enhancing clearance to decrease mutant huntingtin
5 min read
NUB1 increases mutant huntingtin removal from cells, reducing the toxic effects of HD in fruit flies
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Could HD be caused by amino acid deficiency?
7 min read
Does a specific amino acid deficiency contribute to the development of HD?
HDBuzz Trial Tracker
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
