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Picking MSH3’s Pocket: New Insights into CAG Repeat Expansion
8 min read
Latest News
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What Pigs Revealed that Mice Missed in Huntington’s Disease
9 min read
A change in one gene can disrupt thousands of others in HD. A study in pigs suggests an explanation: expanded huntingtin interferes with chemical marks on DNA. The same effect wasn’t seen in mice, showing that the animal model matters.
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Building a Better Mouse(trap): A New Model of Huntington’s Disease
7 min read
New mouse model gives insights into Huntington's disease
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Taking new targets to the bank: the DNA repair protein ‘ATM’ is overactive in Huntington's disease
6 min read
HD causes the normally helpful protein "ATM" to get a little overzealous. Now we can look for drugs to settle it down
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2015 Huntington's Disease Therapeutics Conference: Day 3
10 min read
Day 3 of updates from the annual HD Therapeutics Conference in Palm Springs
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2015 Huntington's Disease Therapeutics Conference: Day 2
8 min read
Day 2 of updates from the annual HD Therapeutics Conference in Palm Springs
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2015 Huntington's Disease Therapeutics Conference: Day 1
10 min read
Day 1 of updates from the annual HD Therapeutics Conference in Palm Springs
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Unlocking the Potential of Antibodies as a Therapy for Huntington’s Disease
4 min read
Antibodies are known for their role in immunity, but researchers repurpose them in many ways. Can they be used in HD?
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Drug Improves Huntington’s Symptoms in Mice – and Their Offspring
7 min read
HD drug changes DNA folding across generations
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mTORC1 tips the scales in Huntington’s disease mice
6 min read
Weighing the scales on mTORC1: A possible new target for HD therapeutics?
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Can this synthetic oil help feed the brain in Huntington's disease?
6 min read
A new study shows a synthetic oil called triheptanoin changes how HD brains use energy. But will it help HD?
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Positive results announced for re-worked tetrabenazine drug in Huntington's disease
8 min read
Modified 'heavy hydrogen' form of tetrabenazine appears safe and effective for chorea in Huntington's disease
HDBuzz Trial Tracker
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
