Articles with the topic: brain-imaging

Focusing in on fibrils; scientists give us a glimpse of huntingtin protein clumps

Focusing in on fibrils; scientists give us a glimpse of huntingtin protein clumps

Scientists have used powerful microscopes to look at sticky fragments of the Huntington’s disease protein, shedding light on these structures which are thought to drive the disease

Dr Rachel HardingSeptember 08, 2022

A new roadmap to track Huntington’s disease progression

A new roadmap to track Huntington’s disease progression

Researchers have updated the system that classifies Huntington’s disease progression. Tracking progression in 4 stages will make clinical trial screening and data interpretation easier and faster, and pave the way for pre-symptomatic trials.

Dr Sarah HernandezJune 15, 2022

Shining a spotlight on huntingtin: a tool to measure huntingtin-lowering in real time

Shining a spotlight on huntingtin: a tool to measure huntingtin-lowering in real time

A new imaging tool means that scientists can now directly measure the levels of the toxic huntingtin protein in animal models of Huntington’s disease, letting us see how well huntingtin lowering therapies are working in their brains

Dr Rachel HardingFebruary 17, 2022

Exciting new Huntingtin lowering tool described

Exciting new Huntingtin lowering tool described

Exciting new Huntingtin Lowering work from @SangamoTx and @CHDIfoundation using "Zinc Fingers" to shut down expression of the mutant Huntingtin gene. More details on this exciting new technique here.

Dr Jeff CarrollAugust 05, 2019

Huntington's disease therapeutics conference 2019 - Day 1

Huntington's disease therapeutics conference 2019 - Day 1

HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs

Joel StantonFebruary 27, 2019

Mapping the anatomy of HD: a whole-brain history

Mapping the anatomy of HD: a whole-brain history

A new book for researchers describes a century of HD anatomy and presents evidence that HD affects the whole brain.

Dr Leora FoxNovember 04, 2015

A faulty filter? Blood vessel changes in Huntington's disease

A faulty filter? Blood vessel changes in Huntington's disease

New research reveals blood vessel changes that could contribute to problem in HD

Melissa ChristiansonMay 13, 2015

The sweet lowdown: Huntington's disease brains use sugar differently

The sweet lowdown: Huntington's disease brains use sugar differently

New observations suggest that the brains of HD mutation carriers consume energy differently. Do we care? (Yes!)

Dr Jeff CarrollOctober 11, 2013

High-power brain scans reveal sodium changes in HD

High-power brain scans reveal sodium changes in HD

A new brain scanning technique reveals high sodium levels in HD brains. How might this help clinical trials?

Dr James ColeAugust 22, 2012