Silencing the Huntingtin gene using ASO drugs reaches further, lasts longer and is safe. Human trial soon?
A new job for a DNA-reading protein called SPT4 - controlling the balance of mutant and healthy huntingtin protein
Day 2 of our coverage of the Huntington's Disease Therapeutics Conference
2 bits of good news for RNAi gene silencing in HD: it's safe over six months, and a way to treat bigger brain areas
Three trials of drugs to 'silence' the HD gene in monkeys show they hit the target safely. Human trials coming soon.
Huntington's disease just got cilia: huntingtin protein affects tiny but important hairs on cells called cilia
Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched
Unzip your genes! A backwards message, hidden in the 'backup DNA' of the Huntington's disease gene... what does it me
Scientists make precise changes to the DNA of a live animal. Could it work for human genetic diseases?