Articles with the topic: cell-model

Taking new targets to the bank: the DNA repair protein ‘ATM’ is overactive in Huntington's disease

Taking new targets to the bank: the DNA repair protein ‘ATM’ is overactive in Huntington's disease

HD causes the normally helpful protein "ATM" to get a little overzealous. Now we can look for drugs to settle it down

Terry Jo BichellMarch 09, 2015

Unlocking the Potential of Antibodies as a Therapy for Huntington’s Disease

Unlocking the Potential of Antibodies as a Therapy for Huntington’s Disease

Antibodies are known for their role in immunity, but researchers repurpose them in many ways. Can they be used in HD?

Lakshini MendisFebruary 18, 2015

Turning skin cells into brain cells: a Huntington's disease research breakthrough?

Turning skin cells into brain cells: a Huntington's disease research breakthrough?

Scientists can now change human skin cells into working neurons, like the ones that are most affected in HD.

Lakshini MendisNovember 27, 2014

NUB1: enhancing clearance to decrease mutant huntingtin

NUB1: enhancing clearance to decrease mutant huntingtin

NUB1 increases mutant huntingtin removal from cells, reducing the toxic effects of HD in fruit flies

Lakshini MendisMay 12, 2014

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Researchers identify Gpx1, a protein that may be protective in HD. An existing drug can mimic its antioxidant effect.

Dr Leora FoxFebruary 05, 2014

New study sheds light on regional degeneration in HD

New study sheds light on regional degeneration in HD

Why do certain brain cells die in HD? New research suggests is may be due to the efficiency of cellular recycling

Dr Kurt JensenNovember 12, 2013

Does a 'rusty hinge' cause Huntington's disease?

Does a 'rusty hinge' cause Huntington's disease?

Canadian scientists have found that the mutant huntingtin protein is less flexible than normal.

Professor Ed WildAugust 27, 2013

The 'N17' region of huntingtin protein: an address label in Huntington's disease?

The 'N17' region of huntingtin protein: an address label in Huntington's disease?

New research sheds light on where the huntingtin protein ends up inside our cells, and why

Joseph OchabaFebruary 26, 2013

Gone fishing:  protein network screen identifies new therapeutic targets in Huntington's disease

Gone fishing: protein network screen identifies new therapeutic targets in Huntington's disease

'Discovery-driven' screen reveals new protein networks involved in Huntington's disease damage & new drug targets

Carly DesmondJanuary 18, 2013