Huntington’s disease slows the cell’s protein factory, causing production line jams & toxicity. A faulty blueprint & missing factory assistant worsen errors. Targeting production slowdowns, not just misfolded products, may help fix the assembly line.
Researchers used plants to study how to stop the Huntington’s disease protein from forming toxic clumps
Scientists have used powerful microscopes to look at sticky fragments of the Huntington’s disease protein, shedding light on these structures which are thought to drive the disease
A successful early trial of a drug for Familial Transthyretic Amyloidosis showed that CRISPR gene editing could be safely used in the human body. What does this mean for gene editing in HD?
Media reports of a wonder drug for neurodegenerative diseases like Huntington's disease are overhyped
Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.
Harmful misfolded huntingtin can travel between brain cells via messenger particles called exosomes
HD brain fluid makes brain cells grow clumps.
Cool lab experiments show the huntington's disease protein jumping between cells. Does this matter for HD patients?