Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: clinical-trial

Prana Biotech's new trial of PBT2 in Huntington's disease: the lowdown

Prana Biotech's new trial of PBT2 in Huntington's disease: the lowdown

Dr Ed Wild on October 03, 2011

Prana Biotech has announced a phase 2 clinical trial in Huntington's disease patients in Australia and the USA. Here's what we know so far about the trial, the company, the drug and the friendship between copper and the mutant huntingtin protein.

Huntexil update: EMA asks for further trial

Huntexil update: EMA asks for further trial

Dr Ed Wild on June 06, 2011

In April, the American drug regulator told NeuroSearch it would need a further large clinical trial before its Huntington's disease symptom-control drug Huntexil would be licensed. Now the European regulator, the EMA, has said the same for European licensing.

Improving Huntington's disease clinical trial recruitment through patient and family education

Improving Huntington's disease clinical trial recruitment through patient and family education

Dr Jeff Carroll on May 12, 2011

Trials of new treatments for Huntington's disease are happening, but proving whether a drug works requires lots of suitable volunteers. Surprisingly, finding enough volunteers is often difficult. Now a group of HD professionals has shown that education and outreach to patients in the community works well for boosting recruitment.

Dimebon fails in late-stage human HD clinical trial

Dimebon fails in late-stage human HD clinical trial

Dr Jeff Carroll on April 11, 2011

Dimebon, an experimental drug marketed by Medivation, fails to improve the symptoms of Huntington’s disease patients in the HORIZON trial. This is the end of the road for developing this drug for HD.

FDA: further trial needed for Huntexil approval in HD

FDA: further trial needed for Huntexil approval in HD

Dr Jeff Carroll on April 04, 2011

NeuroSearch, the developer of experimental Huntington's disease drug Huntexil, has reported on their meeting with the FDA. The FDA requires that another trial be conducted before Huntexil could be approved in the US.

Successful gene therapy trial in Parkinson’s Disease gives hope for HD

Successful gene therapy trial in Parkinson’s Disease gives hope for HD

Dr Jeff Carroll on March 31, 2011

Scientists have successfully used viruses to deliver genes to the brains of Parkinson’s Disease patients. The gene carried by the viruses improved the movement symptoms of patients receiving injections. This proves that gene therapy in the brain can work, providing hope for similar therapies in HD.

Dimebon: disappointing in Alzheimer’s but might work in HD

Dimebon: disappointing in Alzheimer’s but might work in HD

Dr Jeff Carroll on December 23, 2010

Dimebon, a drug developed in Russia as an anti-allergy medication, is under investigation as a possible treatment to improve thinking problems in HD. There was disappointment when a recent large trial of Dimebon to treat Alzheimer’s disease in the USA showed no benefit, but hope remains in HD where the DIMOND trial is continuing across Europe.

Huntexil for symptoms of Huntington's disease: where are we now?

Huntexil for symptoms of Huntington's disease: where are we now?

Dr Ed Wild on November 16, 2010

2010 was a big year for the small Danish pharmacology company NeuroSearch and its experimental drug, Huntexil, which aims to improve the movements and coordination of people with HD symptoms. What have NeuroSearch's two clinical trials - MermaiHD in Europe and HART in the USA - told us about the possible benefits of Huntexil - and what is likely to happen next?

Minocycline: the end of the road?

Minocycline: the end of the road?

Dr Ed Wild on November 10, 2010

The DOMINO study group has published the report of its ‘futility study’ of minocycline treatment in HD. Minocycline and a placebo pill were tested over 18 months. A futility study is designed to make it relatively easy for a drug to be recommended for larger studies, but minocycline treatment wasn’t promising enough and the study authors found that further trials with minocycline were “not warranted”.