Articles with the topic: clinical-trial

HDBuzz primer: Clinical trial designs and phases

HDBuzz primer: Clinical trial designs and phases

HDBuzz untangles hope from hype in clinical trial announcements

Dr Jeff Carroll and Melissa ChristiansonOctober 09, 2015

Measuring harmful huntingtin protein in the brain’s bath water

Measuring harmful huntingtin protein in the brain’s bath water

How will we know whether HD-lowering treatments are working? New advancements in the detection of mutant huntingtin.

Dr Michael OrthMay 18, 2015

2015 Huntington's Disease Therapeutics Conference: Day 2

2015 Huntington's Disease Therapeutics Conference: Day 2

Day 2 of updates from the annual HD Therapeutics Conference in Palm Springs

Dr Jeff CarrollFebruary 26, 2015

Can this synthetic oil help feed the brain in Huntington's disease?

Can this synthetic oil help feed the brain in Huntington's disease?

A new study shows a synthetic oil called triheptanoin changes how HD brains use energy. But will it help HD?

Dr Jeff CarrollJanuary 15, 2015

Positive results announced for re-worked tetrabenazine drug in Huntington's disease

Positive results announced for re-worked tetrabenazine drug in Huntington's disease

Modified 'heavy hydrogen' form of tetrabenazine appears safe and effective for chorea in Huntington's disease

Dr Jeff CarrollDecember 22, 2014

Huntington's disease clinical trial announcement: huntingtin-lowering drug to enter Phase I trial in 2015

Huntington's disease clinical trial announcement: huntingtin-lowering drug to enter Phase I trial in 2015

A clinical trial for an exciting therapy against HD is planned for 2015. The first step is to make sure it is safe.

Leora FoxNovember 04, 2014

Largest creatine clinical trial for Huntington's disease halted after 'futility' analysis

Largest creatine clinical trial for Huntington's disease halted after 'futility' analysis

CREST-E, a trial of the supplement creatine, has been stopped after an early analysis found it couldn't show benefit

Dr Ed WildOctober 29, 2014

2CARE study of coenzyme Q for Huntington's disease ends in disappointment

2CARE study of coenzyme Q for Huntington's disease ends in disappointment

The largest ever HD drug trial, testing coenzyme Q10, is halted for 'futility'. What does that mean for HD research?

Dr Jeff CarrollAugust 13, 2014

HD mice provide a useful failure

HD mice provide a useful failure

Can drug trials that fail be helpful? A HD mouse study provides solid evidence of an approach that doesn't help HD

Dr Jeff CarrollJuly 22, 2014