New interest in an old target

New interest in an old target

Promising results in mice provide renewed optimism for mGluR5 antagonists

Dr Jeff CarrollJanuary 30, 2018

Ask the expert: Q&A on the huntingtin-lowering trial program

Ask the expert: Q&A on the huntingtin-lowering trial program

In a Q&A coordinated by the UK HD Association, Dr Ed Wild answers questions on the recently-announced trial

Dr Ed WildDecember 18, 2017

Success! ASO drug reduces levels of mutant protein in Huntington's disease patients

Success! ASO drug reduces levels of mutant protein in Huntington's disease patients

Amazing news from Ionis and Roche! HTTRx drug successfully lowers harmful huntingtin protein in spinal fluid

Dr Jeff CarrollDecember 11, 2017

Switch off the genome editor when you’re done

Switch off the genome editor when you’re done

CRISPR genome editing just got an off-switch. We cut through the hype to explore the technology in HD

Dr Michael FlowerNovember 02, 2017

A new way of thinking about trials to prevent Huntington's disease

A new way of thinking about trials to prevent Huntington's disease

Can we test drugs to delay or prevent the onset of Huntington's disease? New research suggests it's possible

Dr Jeff CarrollOctober 27, 2017

Update confirms Huntington's disease 'gene silencing' trial on track

Update confirms Huntington's disease 'gene silencing' trial on track

Ionis says its trial of HTTRx, intended to lower huntingtin protein, is fully recruited and plans to extend it

Dr Jeff CarrollOctober 15, 2017

New roles for huntingtin: removing a healthy protein to understand its function

New roles for huntingtin: removing a healthy protein to understand its function

Completely removing normal huntingtin in adults may disrupt healthy brain function, a recent study suggests.

Leora FoxSeptember 26, 2017

Precision huntingtin-lowering drug trials target the mutant protein

Precision huntingtin-lowering drug trials target the mutant protein

WAVE Life Sciences launches PRECISION clinical trial to suppress the mutant Huntington's disease protein

Dr Michael FlowerAugust 25, 2017

A step forward for gene editing: CRISPR-Cas9 and HD

A step forward for gene editing: CRISPR-Cas9 and HD

Evolving CRISPR-Cas9 techniques can now be used to edit the HD gene in a living mouse brain.

Leora FoxJuly 26, 2017

New study reveals a potential HD biomarker

New study reveals a potential HD biomarker

A potential HD biomarker has been uncovered in a recent clinical study

Leora FoxJune 07, 2017

Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)

Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)

Media reports of a wonder drug for neurodegenerative diseases like Huntington's disease are overhyped

Dr Michael FlowerMay 07, 2017