Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: DNA repair

Enemy at the gates – huntingtin disrupts nuclear transport

Enemy at the gates – huntingtin disrupts nuclear transport

Tom Peskett on April 21, 2017

Exciting new studies provide evidence that a particular kind of cellular trafficking goes awry in Huntington's Disease. Specifically, researchers have learned that traffic in and out of the cells control center - the nucleus - breaks down in HD. These findings open up new avenues for HD research.

Huntingtin grabs a hammer: DNA repair in HD

Huntingtin grabs a hammer: DNA repair in HD

Leora Fox on February 22, 2017

DNA damage is a hot topic in HD – and new research offers an intriguing explanation. Canadian researchers have uncovered a potential role for huntingtin in the repair of DNA. They speculate that the normal protein is recruited to the nucleus to provide a supporting scaffold for a construction crew of DNA repair proteins. Mutant huntingtin can commute to the job, but can’t perform.