Articles with the topic: huntingtin-location

Disappointing news from Novartis about branaplam and the VIBRANT-HD trial

Disappointing news from Novartis about branaplam and the VIBRANT-HD trial

Novartis have announced that they are ending development of the drug branaplam in Huntington’s disease. Here, we review this latest news and its impact on the HD community.

Dr Rachel HardingDecember 09, 2022

Enemy at the gates – huntingtin disrupts nuclear transport

Enemy at the gates – huntingtin disrupts nuclear transport

Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.

Tom PeskettApril 21, 2017

Huntingtin grabs a hammer: DNA repair in HD

Huntingtin grabs a hammer: DNA repair in HD

Huntingtin helps fix damaged DNA, a recent study suggests, under the direction of a gene repair protein called ATM.

Dr Leora FoxFebruary 22, 2017

Ultra-rare mutations highlight the importance of the HD gene in brain development

Ultra-rare mutations highlight the importance of the HD gene in brain development

New technology enables researchers to find ultra-rare mutations in the HD gene, distinct from the one causing HD

Megan KrenchAugust 29, 2016

Building a Better Mouse(trap): A New Model of Huntington’s Disease

Building a Better Mouse(trap): A New Model of Huntington’s Disease

New mouse model gives insights into Huntington's disease

Melissa ChristiansonMarch 16, 2015

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