Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: huntingtin-location

Huntingtin grabs a hammer: DNA repair in HD

Huntingtin grabs a hammer: DNA repair in HD

Leora Fox on February 22, 2017

DNA damage is a hot topic in HD – and new research offers an intriguing explanation. Canadian researchers have uncovered a potential role for huntingtin in the repair of DNA. They speculate that the normal protein is recruited to the nucleus to provide a supporting scaffold for a construction crew of DNA repair proteins. Mutant huntingtin can commute to the job, but can’t perform.

Ultra-rare mutations highlight the importance of the HD gene in brain development

Ultra-rare mutations highlight the importance of the HD gene in brain development

Megan Krench on August 29, 2016

A relatively new technology called exome sequencing has identified a few families with novel mutations in their HD genes. These are different than the mutation that causes HD, but allow researchers to better understand the normal role of the HD gene.

Building a Better Mouse(trap): A New Model of Huntington’s Disease

Building a Better Mouse(trap): A New Model of Huntington’s Disease

Melissa Christianson on March 16, 2015

Most research on Huntington’s disease is done using animal models that mimic the human disease. However, these models typically recreate only a few of the disease’s symptoms, and there are some important symptoms that don’t show up in any model at all. Now, exciting new research is making great strides against these problems – and teaching us about the disease at the same time.