Articles with the topic: featured

Two birds, one stone: HTT-lowering drugs also target CAG expansions

Two birds, one stone: HTT-lowering drugs also target CAG expansions

In a surprising twist, oral HTT-lowering drugs also slow somatic expansion in the HTT gene. A new study that used cells in a dish for this fortuitous discovery identified the gene PMS1 as a key player in the slowing of CAG expansions.

Dr Sarah HernandezMay 21, 2024

Hats off to brain donors on Brain Donation Awareness Day

Hats off to brain donors on Brain Donation Awareness Day

May 7 is Brain Donation Awareness Day. Today we highlight the selfless donation that many HD families have made, sending our gratitude, sharing research updates made with those precious brains, and detailing resources for brain donation.

Dr Sarah HernandezMay 07, 2024

A sprinkling of good news for the treatment of HD chorea

A sprinkling of good news for the treatment of HD chorea

A new form of the chorea drug valbenazine (INGREZZA) has been approved by the United States Food and Drug Administration (FDA) for those who have difficulty swallowing pills.

Dr Leora FoxMay 03, 2024

A new era for HDBuzz

A new era for HDBuzz

For over a decade HDBuzz has reported unbiased news about Huntington’s disease research and trials. As our beloved Ed and Jeff step back, Rachel, Sarah, and Leora look forward to upholding the HDBuzz mission.

Dr Sarah Hernandez, Dr Leora Fox, and Dr Rachel HardingMay 01, 2024

How many is too many? Exploring the toxic CAG threshold in the Huntington’s disease brain

How many is too many? Exploring the toxic CAG threshold in the Huntington’s disease brain

New work from researchers in London uses mice to narrow in on the number of CAG repeats needed to cause symptoms of Huntington’s disease. Their work points to fewer than 185 CAGs as a threshold.

Dr Chris KayApril 21, 2024

Cry your eyes out: detecting huntingtin in tears

Cry your eyes out: detecting huntingtin in tears

Is someone cutting onions? Expanded huntingtin can now be detected in tears to help scientists track disease progression.

Dr Sarah HernandezApril 10, 2024

The director’s cut: how CAG repeats change the editing of genetic messages

The director’s cut: how CAG repeats change the editing of genetic messages

Scientists in Massachusetts have recently advanced our understanding of how repetitive sequences in DNA can disrupt the creation and editing of genetic messenger molecules in cells, and how this could lead to the production of harmful proteins.

Lucy CouplandMarch 26, 2024

Understanding expansions at the single cell level

Understanding expansions at the single cell level

Scientists have looked at CAG expansions in brains from people with HD to see which cells are affected

Dr Rachel HardingMarch 12, 2024

Huntington's Disease Therapeutics Conference 2024 - Day 3

Huntington's Disease Therapeutics Conference 2024 - Day 3

Dr Rachel Harding, Dr Leora Fox, and Dr Sarah HernandezMarch 07, 2024