Articles with the topic: featured

Stopping C-A-G Repeat Expansion In Its Tracks

Stopping C-A-G Repeat Expansion In Its Tracks

A new study shows that lowering MSH3, a key DNA repair protein, with antisense oligonucleotide (ASO) therapy can stop CAG repeat expansions in HD patient-derived brain cells. This could be a promising way to slow symptom onset and progression.

Dr Nicholas CaronApril 24, 2025

Ten Golden Rules for Navigating Huntington’s Disease Research News

Ten Golden Rules for Navigating Huntington’s Disease Research News

Avoid the hype: HDBuzz has Ten Golden Rules for navigating news stories or press releases about Huntington's disease.

Dr Rachel HardingApril 21, 2025

Roche provides an update on tominersen: What’s next for this huntingtin-lowering drug?

Roche provides an update on tominersen: What’s next for this huntingtin-lowering drug?

Roche gave an update this week about GENERATION HD2, testing the HTT-lowering drug tominersen in people with HD. The trial is continuing, but only the higher dose will move forward. What does this update mean for the HD community and this trial?

Dr Rachel Harding and Dr Sarah HernandezApril 17, 2025

Knockouts for the win: how expanding CAGs drive disease

Knockouts for the win: how expanding CAGs drive disease

A recent paper links CAG repeat expansion with widespread RNA changes, especially in brain cells vulnerable to HD. “Knocking out” certain DNA repair genes that go awry in HD can have positive effects on features of HD in mice.

Dr Leora FoxApril 14, 2025

Piecing It Back Together: Growing new neurons for Huntington’s disease

Piecing It Back Together: Growing new neurons for Huntington’s disease

New research suggests the adult brain can be convinced to grow new neurons to replace those lost in Huntington’s disease. The SUPER exciting part? These cells don’t just grow—they seem to connect and function, like puzzle pieces clicking into place.

Dr Sarah HernandezApril 10, 2025

Stars in the Sky: Psychosis in Huntington’s Disease

Stars in the Sky: Psychosis in Huntington’s Disease

New research shines a light on an often-overlooked side of Huntington’s disease—psychosis. Understanding the impact of psychosis on daily life and progression of other HD symptoms could be key to providing better care and support.

Maille (Molly) GraceyApril 07, 2025

Hope in Full Bloom: Why Your Support Matters Now More Than Ever

Hope in Full Bloom: Why Your Support Matters Now More Than Ever

Hope is in full bloom at HDBuzz! We’re growing—doubling article output, expanding our team, & keeping Huntington’s disease families informed. Now, we need YOUR help to stay independent & strong. Donate today & fuel free, trusted HD research news!

Dr Sarah HernandezApril 01, 2025

March 2025: This Month in Huntington’s Disease Research

March 2025: This Month in Huntington’s Disease Research

With so much science going on in the Huntington’s disease space, we’re bringing you a monthly recap from March 2025 to cover all the biggest HD science news and research we covered this month. Enjoy!

Dr Sarah HernandezMarch 31, 2025

Molecular Surgeons for Huntington’s Disease Catch a RIDE with CRISPR Advancements

Molecular Surgeons for Huntington’s Disease Catch a RIDE with CRISPR Advancements

A new CRISPR-based technology, called RIDE, is a leap forward for this trail-blazing technology. With the precision of a scalpel sharp enough to rewrite the very code of life, researchers have used it with the hope of treating Huntington’s disease.

Dr Sarah HernandezMarch 27, 2025

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