Articles with the topic: huntingtin-function

Hunting for balance: how the huntingtin protein compensates in HD

Hunting for balance: how the huntingtin protein compensates in HD

Researchers look at the cause and effect of various forms of the HTT protein. They find both expanded and unexpanded HTT contribute to brain cell communication and the brain has an amazing capacity to compensate for changes related to disease

Dr Sarah Hernandez and Dr Leora FoxApril 05, 2023

Working as a team: Changes in brain development mean some brain regions may be slacking off

Working as a team: Changes in brain development mean some brain regions may be slacking off

Scientists use human fetal tissue to look at HD brain development. But what do developmental changes mean when symptoms don’t occur until decades after birth?

Dr Sarah HernandezAugust 17, 2020

Fountain of youth: HTT protein repairs neurons by maintaining youthful state

Fountain of youth: HTT protein repairs neurons by maintaining youthful state

Another clue about the normal function of the huntingtin protein; a team of scientists has recently found that huntingtin seems to play an important role in repairing damaged nerve cells

Dr Rachel Harding and Dr Sarah HernandezMay 13, 2020

Huntington’s disease therapeutics conference 2020 - Day 1

Huntington’s disease therapeutics conference 2020 - Day 1

HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs

Dr Rachel Harding, Dr Sarah Hernandez, and Joel StantonMarch 12, 2020

Screening the entire genome for new drug targets for HD

Screening the entire genome for new drug targets for HD

Scientists screen the ENTIRE genome to find new potential therapeutic targets for HD. This ambitious study provides a wealth of data for HD researchers

Dr Rachel HardingFebruary 23, 2020

The third dimension: using minibrains to understand brain development changes in HD

The third dimension: using minibrains to understand brain development changes in HD

Researchers show that highly expanded CAGs in the HD gene can cause early developmental changes using 3D brain models called organoids. What’d they find?

Dr Sarah HernandezFebruary 06, 2020

Huntington's disease therapeutics conference 2019 - Day 3

Huntington's disease therapeutics conference 2019 - Day 3

New insights into the huntingtin protein, and further progress in turning genetic quirks that modify the course of HD into treatments, on the final day of the therapeutics conference

Joel Stanton and Dr Jeff CarrollMarch 05, 2019

Huntington's disease therapeutics conference 2018 - day 3

Huntington's disease therapeutics conference 2018 - day 3

Updates from day 3 of the Huntington’s Disease Therapeutics Conference: huntingtin protein - and lowering it

Dr Jeff CarrollMarch 02, 2018

An early role for the Huntington's disease gene – but don't believe all the headlines

An early role for the Huntington's disease gene – but don't believe all the headlines

A surprising new paper sheds light on the role of the HD gene early in development. Should we worry?

Dr Jeff CarrollFebruary 27, 2018

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