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The benefits of migration, highlighted in Huntington's disease

The benefits of migration, highlighted in Huntington's disease

Is HD a developmental disease? HD stops neurons migrating in developing brain, but maybe we can get them going again

Dr Michael FlowerFebruary 10, 2017

New roles for huntingtin: removing a healthy protein to understand its function

New roles for huntingtin: removing a healthy protein to understand its function

Completely removing normal huntingtin in adults may disrupt healthy brain function, a recent study suggests.

Dr Leora FoxSeptember 26, 2017

Switch off the genome editor when you’re done

Switch off the genome editor when you’re done

CRISPR genome editing just got an off-switch. We cut through the hype to explore the technology in HD

Dr Michael FlowerNovember 02, 2017

Success! ASO drug reduces levels of mutant protein in Huntington's disease patients

Success! ASO drug reduces levels of mutant protein in Huntington's disease patients

Amazing news from Ionis and Roche! HTTRx drug successfully lowers harmful huntingtin protein in spinal fluid

Dr Jeff CarrollDecember 11, 2017

Exciting new Huntingtin lowering tool described

Exciting new Huntingtin lowering tool described

Exciting new Huntingtin Lowering work from @SangamoTx and @CHDIfoundation using "Zinc Fingers" to shut down expression of the mutant Huntingtin gene. More details on this exciting new technique here.

Dr Jeff CarrollAugust 05, 2019

Start here!

Start here!

Huntington's disease research news. In plain language. Written by scientists. For the global HD community.

Professor Ed Wild, Dr Leora Fox, Dr Rachel Harding, Dr Sarah Hernandez, and Dr Jeff CarrollMay 22, 2023

Could halting CAG expansions be a new treatment for HD?

Could halting CAG expansions be a new treatment for HD?

The gene MSH3 is getting a lot of attention in HD research lately. New findings suggest MSH3 lowering could halt CAG repeat expansions, offering a new therapeutic avenue.

Dr Sarah HernandezOctober 05, 2023

Are there genetic connections between neurodegenerative diseases?

Are there genetic connections between neurodegenerative diseases?

Genetic evidence suggests connections between a polyQ disease and ALS (Lou Gehrig’s disease). Why should HD people ca

Dr Jeff CarrollDecember 01, 2010

The genetic 'gray area' of Huntington's disease: what does it all mean?

The genetic 'gray area' of Huntington's disease: what does it all mean?

Intermediate alleles and reduced penetrance – the genetic 'gray area' of Huntington’s disease, explained

Dr Nayana LahiriApril 22, 2011

Gene therapy meets stem cells in liver disease success

Gene therapy meets stem cells in liver disease success

Scientists combine gene therapy and stem cells to correct a genetic liver disease. Could this combo be retooled for H

Dr Michael OrthDecember 26, 2011

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