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Beyond huntingtin lowering: out-of-the-box approaches for the treatment of HD
The HD pipeline is rich and varied. Let's talk about some out-of-the-box approaches for developing drugs for HD that don't involve huntingtin lowering.
November 24, 2023
Regulating repetition: Gaining control of CAG repeats could slow progression of Huntington’s disease
Many diseases are caused by repetitive DNA sequences. Understanding the regulation of those repetitive sequences may hold the key for unlocking therapeutics for Huntington’s disease. A team from Toronto has just advanced our understanding.
November 30, 2023
CRISPR-based drugs: one giant leap for mankind
Casgevy is the first CRISPR-based drug to make its way through the approval process, all but curing Sickle Cell Disease and it’s paving the way for similar drugs targeting other diseases. Is Huntington’s disease next?
February 14, 2024
Huntington's Disease Therapeutics Conference 2024 - Day 1
Check out research updates from Day 1 of the 2024 HD Therapeutics Conference #HDTC2024
March 05, 2024
Huntington's Disease Therapeutics Conference 2024 - Day 2
March 06, 2024
Huntington's Disease Therapeutics Conference 2024 - Day 3
March 07, 2024
Understanding expansions at the single cell level
Scientists have looked at CAG expansions in brains from people with HD to see which cells are affected
March 12, 2024
Making babies: having a family, the HD way
Making babies: HDBuzz's feature article - updated for 2024 - on fertility technologies that can help at-risk people to have HD-free children
March 16, 2024
Cry your eyes out: detecting huntingtin in tears
Is someone cutting onions? Expanded huntingtin can now be detected in tears to help scientists track disease progression.
April 10, 2024
How many is too many? Exploring the toxic CAG threshold in the Huntington’s disease brain
New work from researchers in London uses mice to narrow in on the number of CAG repeats needed to cause symptoms of Huntington’s disease. Their work points to fewer than 185 CAGs as a threshold.
April 21, 2024
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