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The genetic 'gray area' of Huntington's disease: what does it all mean?
Intermediate alleles and reduced penetrance – the genetic 'gray area' of Huntington’s disease, explained
April 22, 2011
Gene silencing takes a targeted step forward
Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched
October 07, 2011
Safety trials add crucial piece to gene silencing jigsaw
Three trials of drugs to 'silence' the HD gene in monkeys show they hit the target safely. Human trials coming soon.
November 14, 2011
New analysis suggests 'small' CAG length doesn't matter after all
Size isn't everything: new research suggests that only a person's big CAG count, not the small one, affects HD onset
February 18, 2012
Does the HD mutation affect children's growth?
A small study suggests kids with the HD mutation but no symptoms have subtle differences in growth. What does it mean
August 07, 2012
HDBuzz Prize runner-up 2012: Fruit flies, faulty connections and Huntington's disease
Recent study in fruit flies identifies a new connection between synapses and HD
November 16, 2012
Major Roche-Isis deal boosts Huntington's disease gene silencing
'ASO' gene silencing drugs for HD boosted by major deal between Isis Pharmaceuticals and Roche
April 09, 2013
Landmark study puts Huntington's disease trials on TRACK
Final results from the TRACK-HD study show very specific changes in HD. We're ready for trials: bring on the drugs!
May 09, 2013
A DNA repair protein modifies the stability of long CAG tracts in the Huntington's disease gene
DNA repair is a critical process to cells, but errors in this process might explain 'repeat instability' in HD
June 03, 2013
Gene silencing drug safe in ALS patients... bring on Huntington's disease trials
Gene silencing drug injected into spinal fluid in ALS patients proves safe. Good news for similar planned HD trials.
June 29, 2013
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