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Can’t Get You Out of My Head: The Huntington’s Disease Symptom That’s More Than Just Repetition
5 min read
Latest News
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AMT-130 at Four Years: Hopeful Signs, Complex Controls
12 min read
uniQure reports that after 4 years, people given high-dose AMT-130 continue to show signs of slower HD progression, providing hope for their recent regulatory submission. But the new analyses are nuanced. We unpack the hopeful, but complex results.
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Working as a team: Changes in brain development mean some brain regions may be slacking off
8 min read
Scientists use human fetal tissue to look at HD brain development. But what do developmental changes mean when symptoms don’t occur until decades after birth?
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Caution urged for the use of gene-editing technology CRISPR
5 min read
A recent series of studies on the gene-editing method CRISPR have raised concerns about the suitability of this technology for the treatment of genetic illnesses such as Huntington's disease
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HD and Histamines: Targeting Hybrid Receptors to Quiet Stressful Brain Talk
9 min read
Scientists recently used an antihistamine to quiet dopamine messages in the brain and treat HD-like symptoms in mice. But beware the hype suggesting that allergy medicines could be used to slow down HD.
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Changing jobs: converting other cell types into neurons
7 min read
Because HD causes a loss of neurons in the brain, some researchers are exploring ways to replace them. Working with HD mice, scientists recently showed that supportive brain cells called glia can be coaxed into becoming new neurons.
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HD Young Adult Study defines the sweet spot: symptom-free with measurable changes
7 min read
We know that HD-related changes can occur many years before symptom onset, but how early do those changes begin? A team of researchers set out to determine that with a new comprehensive study in pre-manifest HD young adults.
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Fountain of youth: HTT protein repairs neurons by maintaining youthful state
5 min read
Another clue about the normal function of the huntingtin protein; a team of scientists has recently found that huntingtin seems to play an important role in repairing damaged nerve cells
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What does COVID-19 mean for Huntington’s disease families and HD research?
9 min read
COVID-19 update: what does it mean for HD families, how does it impact HD research, and how has it changed the way science works?
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New molecule can reverse the Huntington's disease mutation in lab models
6 min read
A collaborative team of scientists from Canada and Japan have identified a small molecule which can change the CAG-repeat length in different lab models of Huntington's disease. #HuntingtonsDisease #DrugDiscovery
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Huntington’s disease therapeutics conference 2020 – Day 3
16 min read
HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs
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Huntington’s disease therapeutics conference 2020 – Day 2
7 min read
HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs
HDBuzz Trial Tracker
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
