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Could rewiring the brain’s “brakes” improve movement in Huntington’s disease?
6 min read
Latest News
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A new era for HDBuzz
12 min read
For over a decade HDBuzz has reported unbiased news about Huntington’s disease research and trials. As our beloved Ed and Jeff step back, Rachel, Sarah, and Leora look forward to upholding the HDBuzz mission.
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How many is too many? Exploring the toxic CAG threshold in the Huntington’s disease brain
6 min read
New work from researchers in London uses mice to narrow in on the number of CAG repeats needed to cause symptoms of Huntington’s disease. Their work points to fewer than 185 CAGs as a threshold.
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Cry your eyes out: detecting huntingtin in tears
5 min read
Is someone cutting onions? Expanded huntingtin can now be detected in tears to help scientists track disease progression.
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The director’s cut: how CAG repeats change the editing of genetic messages
7 min read
Scientists in Massachusetts have recently advanced our understanding of how repetitive sequences in DNA can disrupt the creation and editing of genetic messenger molecules in cells, and how this could lead to the production of harmful proteins.
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Understanding expansions at the single cell level
8 min read
Scientists have looked at CAG expansions in brains from people with HD to see which cells are affected
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Huntington's Disease Therapeutics Conference 2024 – Day 3
17 min read
HDBuzz is back for the last day of the CHDI HD Therapeutics Conference: Thursday February 29th in Palm Springs, California. This article summarizes our real-time updates of the conference in community-friendly language. From genes to medicines The morning session will focus on how human genetics is driving the development of therapeutics. “Genetic modifiers” are genes…
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Huntington's Disease Therapeutics Conference 2024 – Day 2
13 min read
HDBuzz is back for Day 2 of the CHDI HD Therapeutics Conference: Wednesday February 28th in Palm Springs, California. This article summarizes our real-time updates of the conference in community-friendly language. It’s a brain disease This morning’s session is titled “It’s a brain disease” and will feature talks about BRAINSSSS! HD scientists are a bit…
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Huntington's Disease Therapeutics Conference 2024 – Day 1
24 min read
Check out research updates from Day 1 of the 2024 HD Therapeutics Conference #HDTC2024
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CRISPR-based drugs: one giant leap for mankind
10 min read
Casgevy is the first CRISPR-based drug to make its way through the approval process, all but curing Sickle Cell Disease and it’s paving the way for similar drugs targeting other diseases. Is Huntington’s disease next?
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Steady progress from uniQure – promising data to end the year
7 min read
uniQure ushered in the end of the year by releasing some promising data from their huntingtin-lowering gene therapy trials
HDBuzz Trial Tracker
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
