Latest news

Interim update from Vico Therapeutics on their CAG-targeting drug, VO659

Interim update from Vico Therapeutics on their CAG-targeting drug, VO659

Vico Therapeutics have shared interim data about their drug, VO659, which targets the CAG expansion that causes several genetic diseases, including #Huntingtonsdisease and #spinocerebellarataxia

Dr Rachel HardingDecember 10, 2024

Moving into the Fast Lane: uniQure and the FDA Are on the Same Track for Accelerated Approval

Moving into the Fast Lane: uniQure and the FDA Are on the Same Track for Accelerated Approval

In an update shared today, uniQure announced alignment with the US drug regulator on key criteria for accelerated approval of drugs for Huntington’s disease.

Dr Rachel Harding and Dr Sarah HernandezDecember 10, 2024

Going boldly: First person treated in Phase 1 clinical trial by Alnylam Pharmaceuticals

Going boldly: First person treated in Phase 1 clinical trial by Alnylam Pharmaceuticals

A new Phase 1 clinical trial for the huntingtin-lowering drug ALN-HTT02 was initiated this week with the first dose given. Read on to learn details about the trial and how it compares to other ongoing huntingtin-lowering trials in the clinic.

Dr Sarah HernandezDecember 08, 2024

Giving Thanks to the Huntington's Disease Family Community for Advancing Research

Giving Thanks to the Huntington's Disease Family Community for Advancing Research

At this time of giving, we want to give thanks to you, the Huntington’s disease (HD) community, for all you have done for HD research, bringing us closer to medicines which will one day slow or halt HD.

HDBuzz EditorsDecember 03, 2024

Self-determination on the HD journey: the role of Advanced Care Planning

Self-determination on the HD journey: the role of Advanced Care Planning

Advanced Care Planning is a tool that can allow people living with Huntington’s disease to compassionately engage with loved ones about their future care, taking thoughtful steps at their own pace while they’re able, to ensure their wishes are met.

Dr Tamara MaiuriDecember 02, 2024

2024 HDBuzz Prize: Beyond nerve cells – who are the other players in the HD brain?

2024 HDBuzz Prize: Beyond nerve cells – who are the other players in the HD brain?

We're proud to announce Jenny Lange as a 2024 HDBuzz Prize winner! Our brains are made up of many types of cells that play different roles in the changes caused by HD. This study dives into a star-shaped cell called astrocytes and their role in HD.

Dr Jenny LangeNovember 25, 2024

Face-to-face: Huntington’s disease families are heard by the FDA

Face-to-face: Huntington’s disease families are heard by the FDA

The HDSA recently coordinated a meeting between Huntington’s disease families and the US regulatory agency that approves medicines, to amplify the community’s voice and help move us toward treatments.

Dr Sarah HernandezNovember 22, 2024

The dust has settled: Sage’s dalzanemdor won’t advance for cognitive impairment

The dust has settled: Sage’s dalzanemdor won’t advance for cognitive impairment

Changes in thinking, learning, and memory are some of the most distressing and impactful in Huntington’s disease. Sage Therapeutics was advancing their drug dalzanemdor to treat these symptoms, but unfortunately this program will be halted.

Dr Sarah HernandezNovember 20, 2024

We are not alone, and are seeing more RED

We are not alone, and are seeing more RED

Scientists have found more people have the genetic changes that underlie repeat expansion diseases, like HD, than previously thought. This new data tells doctors to consider expansion diseases more when diagnosing people with neurological symptoms.

Dr Ray TruantNovember 18, 2024

Huntington Study Group (HSG) Conference 2024 – Day 3

Huntington Study Group (HSG) Conference 2024 – Day 3

Read updates from clinical trials and scientific research on Huntington’s disease from Day 3 of the 2024 Huntington Study Group conference.

Dr Leora Fox and Dr Sarah HernandezNovember 13, 2024

Huntington Study Group (HSG) Conference 2024 – Day 1

Huntington Study Group (HSG) Conference 2024 – Day 1

Read updates from clinical trials and scientific research on Huntington’s disease from Day 1 of the 2024 Huntington Study Group conference #HSG2024

Dr Leora Fox and Dr Sarah HernandezNovember 12, 2024

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