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Could rewiring the brain’s “brakes” improve movement in Huntington’s disease?
6 min read
Latest News
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Your Voice Matters: Using Speech to Monitor Huntington’s Disease
9 min read
HD researchers developed an AI-powered tool that analyzes a short counting task. Its speech measures reflected clinical scores and HD-related changes over time, suggesting it could be used as a remote monitoring tool in future.
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Can’t Get You Out of My Head: The Huntington’s Disease Symptom That’s More Than Just Repetition
5 min read
Getting “stuck” on a thought, action, or conversation can be a symptom of HD—not stubbornness. New research suggests perseveration may begin earlier than previously thought and highlights the value of caregiver perspectives.
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AMT-130 at Four Years: Hopeful Signs, Complex Controls
12 min read
uniQure reports that after 4 years, people given high-dose AMT-130 continue to show signs of slower HD progression, providing hope for their recent regulatory submission. But the new analyses are nuanced. We unpack the hopeful, but complex results.
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September 2026: This month in Huntington’s disease research
5 min read
September brought progress across the HD research landscape. From brain waves and visual thinking to DNA repeats, nutrition, inclusive care, new technologies, and encouraging SKY-0515 data, we round up a busy month in Huntington’s disease research.
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Studying Stutters: What 900,000 genomes teach us about growing DNA repeats
7 min read
The CAG repeat that causes HD has a tendency to grow with age. New research on over 900,000 people uncovers parallel patterns and finds CAG growth can happen in many other parts of the genome.
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Highlighting Mental Health Disparities in Indigenous Communities Affected by Huntington’s Disease
11 min read
Unique research highlights an overlooked mental health disparity among Indigenous North American people with HD – and the need for care grounded in trust, community partnership, and cultural understanding.
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Encouraging news from Skyhawk, as SKY-0515 Phase 1/2 data continues to hold promise
10 min read
Skyhawk shared data at the 15 month mark for SKY-0515 treatment in people with HD in their Phase 1/2 trial. The drug is working as designed and there are some encouraging signs that it could be helpful for some symptoms of HD.
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Food for Thought: The Importance of Nutrition in Huntington’s Disease
8 min read
What if nutrition is one of the warning lights we should be checking earlier in Huntington’s disease? New research suggests simple nutrition measures may help identify when people with HD need extra support.
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Could Brain Waves Help Track Huntington’s Disease?
7 min read
A review of 23 studies found that EEG changes were linked to disease progression and clinical measures in HD. While more research is needed, EEG holds potential to become a simple, non-invasive biomarker for monitoring HD over time.
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Hot techniques in HD research
11 min read
Five HD scientists discuss the cutting-edge techniques driving their work. These technical innovations will provide biological insights and move us closer to treatments.
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Keeping an Eye on HD: Can Visual Thinking Skills Help Track Disease Progression?
7 min read
What if Huntington’s disease changes how we “see” the world before we even notice symptoms? New research suggests visual thinking skills may help track HD progression over time.
HDBuzz Trial Tracker
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
