mouse-model
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Of mice and men: using animal models to study Huntington's disease
Animal models of Huntington's disease: what they tell us about the disease and how can they help develop new therapie
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Shooting the messenger with single-stranded RNA gene silencing
New ‘single-stranded RNA’ gene silencing drugs could be safer & more effective to treat Huntington’s disease
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Lithium with a twist gets second chance for HD
Lithium gets a second chance in HD – with a new chemical delivery method, tested in Huntington’s disease mice
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Mapping the neighborhood: huntingtin's new protein partners
Study of huntingtin protein's 'neighbors' reveals dozens of new drug development targets
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Special 'brain fat' injection helps HD mice
Directly injecting the brains of HD mice with a good type of fat called ganglioside GM1 provides dramatic benefit
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Turning down the volume with dantrolene helps HD mice
Dantrolene, an muscle-relaxer drug already on the market, helps HD mice by reducing cellular calcium levels
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Gene silencing takes a targeted step forward
Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched