mouse-model
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The benefits of migration, highlighted in Huntington's disease
6 min read
Is HD a developmental disease? HD stops neurons migrating in developing brain, but maybe we can get them going again
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Early exposure to the HD protein may cause life-long symptoms
8 min read
A surprising new mouse study suggests the mutant HD gene may do some of its damage during embryonic development
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Huntingtin takes a trip: harmful proteins pass between brain cells
7 min read
Harmful misfolded huntingtin can travel between brain cells via messenger particles called exosomes
By Dr Leora Fox -
A recycled drug gives us new insight in to HD
7 min read
An existing drug could give a boost to HD brain cells – but it may need more testing before it’s back in the clinic
By Dr Leora Fox -
A multiple sclerosis drug that works for Huntington's disease: the real deal or too good to be true?
8 min read
Fingolimod, a drug used in multiple sclerosis, prevents memory problems in HD mice. Would it work in patients?
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New tool to measure outcomes in Huntington’s Disease clinical trials
6 min read
A better tool for HD trials! New research shows innovative way to measure mutant Huntingtin outside the brain
By Megan Krench -
A faulty filter? Blood vessel changes in Huntington's disease
7 min read
New research reveals blood vessel changes that could contribute to problem in HD
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Novel research technique suggests an antioxidant gene protects vulnerable neurons
8 min read
Researchers use a new technique in an HD mouse to uncover a gene, Gpx6, that is protective to vulnerable neurons.
By Dr Leora Fox -
Building a Better Mouse(trap): A New Model of Huntington’s Disease
7 min read
New mouse model gives insights into Huntington's disease
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Taking new targets to the bank: the DNA repair protein ‘ATM’ is overactive in Huntington's disease
6 min read
HD causes the normally helpful protein "ATM" to get a little overzealous. Now we can look for drugs to settle it down