aggregates
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2025 HDBuzz Prize: On the Frontlines: Trusting the Hall Monitors of the Cell
We’re proud to announce Chloe Langridge as a 2025 HDBuzz Prize winner! A protein called SGTA shows promise as a target in HD therapeutics. Researchers find that increasing levels of SGTA in the cell helps reduce signs of HD.
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Peeking at huntingtin and learning from a PET study
Scientists tested a new tool to measure harmful HTT protein in HD. It wasn’t perfect, but offered key insights to guide better tools already in the works. A big step toward tracking HD non-invasively, from inside the brain!
By Dr Leora Fox -
Assembly Line Breakdown: Protein Production Problems in Huntington’s Disease
Huntington’s disease slows the cell’s protein factory, causing production line jams & toxicity. A faulty blueprint & missing factory assistant worsen errors. Targeting production slowdowns, not just misfolded products, may help fix the assembly line.
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Getting to the Root of Huntington's Disease: A Plant-Based Approach
Researchers used plants to study how to stop the Huntington’s disease protein from forming toxic clumps
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Focusing in on fibrils; scientists give us a glimpse of huntingtin protein clumps
Scientists have used powerful microscopes to look at sticky fragments of the Huntington’s disease protein, shedding light on these structures which are thought to drive the disease
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A first for CRISPR gene editing could have wider applications for human disease
A successful early trial of a drug for Familial Transthyretic Amyloidosis showed that CRISPR gene editing could be safely used in the human body. What does this mean for gene editing in HD?
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Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)
Media reports of a wonder drug for neurodegenerative diseases like Huntington's disease are overhyped
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Enemy at the gates – huntingtin disrupts nuclear transport
Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.
By Tom Peskett -
Huntingtin takes a trip: harmful proteins pass between brain cells
Harmful misfolded huntingtin can travel between brain cells via messenger particles called exosomes
By Dr Leora Fox -
A Few Bad Seeds: Using Brain Fluid to Grow Clumps in Brain Cells
HD brain fluid makes brain cells grow clumps.