aggregates
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2025 HDBuzz Prize: On the Frontlines: Trusting the Hall Monitors of the Cell
5 min read
We’re proud to announce Chloe Langridge as a 2025 HDBuzz Prize winner! A protein called SGTA shows promise as a target in HD therapeutics. Researchers find that increasing levels of SGTA in the cell helps reduce signs of HD.
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Peeking at huntingtin and learning from a PET study
9 min read
Scientists tested a new tool to measure harmful HTT protein in HD. It wasn’t perfect, but offered key insights to guide better tools already in the works. A big step toward tracking HD non-invasively, from inside the brain!
By Dr Leora Fox -
Assembly Line Breakdown: Protein Production Problems in Huntington’s Disease
6 min read
Huntington’s disease slows the cell’s protein factory, causing production line jams & toxicity. A faulty blueprint & missing factory assistant worsen errors. Targeting production slowdowns, not just misfolded products, may help fix the assembly line.
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Getting to the Root of Huntington's Disease: A Plant-Based Approach
5 min read
Researchers used plants to study how to stop the Huntington’s disease protein from forming toxic clumps
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Focusing in on fibrils; scientists give us a glimpse of huntingtin protein clumps
7 min read
Scientists have used powerful microscopes to look at sticky fragments of the Huntington’s disease protein, shedding light on these structures which are thought to drive the disease
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A first for CRISPR gene editing could have wider applications for human disease
5 min read
A successful early trial of a drug for Familial Transthyretic Amyloidosis showed that CRISPR gene editing could be safely used in the human body. What does this mean for gene editing in HD?
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Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)
8 min read
Media reports of a wonder drug for neurodegenerative diseases like Huntington's disease are overhyped
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Enemy at the gates – huntingtin disrupts nuclear transport
7 min read
Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.
By Tom Peskett -
Huntingtin takes a trip: harmful proteins pass between brain cells
7 min read
Harmful misfolded huntingtin can travel between brain cells via messenger particles called exosomes
By Dr Leora Fox -
A Few Bad Seeds: Using Brain Fluid to Grow Clumps in Brain Cells
7 min read
HD brain fluid makes brain cells grow clumps.