Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

Are you looking for our logo? You can download our logo and get information about how to use it on our sharing page

Articles with the topic: featured

EuroBuzz 2014: day one

EuroBuzz 2014: day one

Dr Ed Wild on September 19, 2014

Join Jeff and Ed as we tweet live from the 2014 European Huntington's Disease Network meeting in Barcelona! Exciting science ahead!

2CARE study of coenzyme Q for Huntington's disease ends in disappointment

2CARE study of coenzyme Q for Huntington's disease ends in disappointment

Dr Jeff Carroll on August 13, 2014

The largest ever therapeutic trial for Huntington's disease was halted early this week because an analysis of the results to date showed that it was very unlikely to show positive results. The study, called 2CARE, was designed to test whether a treatment called coenzyme Q10 could slow the progression of HD.

The brain in Huntington's disease: greater than the sum of its parts?

The brain in Huntington's disease: greater than the sum of its parts?

Dr Jeff Carroll on May 19, 2014

The symptoms of HD are caused by damage to the brain, but not all parts of the brain are affected equally. This raises an important question - if we had a treatment that could help only a small part of the brain, which part would we pick? A new mouse study from William Yang, at UCLA, attempts to answer this question.

Could HD be caused by amino acid deficiency?

Could HD be caused by amino acid deficiency?

Dr Jeff Carroll on April 21, 2014

All the proteins in our body are made of tiny chemical building blocks, called amino acids. The internet was recently buzzing about a newly discovered link between one of these amino acids, cysteine, and Huntington's Disease. Is it true, as some headlines suggested, that "Brain Degeneration In Huntington’s Disease Caused By Amino Acid Deficiency"?

Sleep, cilia and HD

Sleep, cilia and HD

Graham Easton on March 06, 2014

Studies have shown that HD patients tend to get less efficient sleep, fewer hours of sleep, and wake up more times during the night. However, sleep in Huntington’s is under-researched because historically scientists have investigated HD as a disease of movement impairment, and sleep problems don’t seem to have anything to do with movement impairment.

Prana announces results of Reach2HD trial of PBT2 for Huntington's disease

Prana announces results of Reach2HD trial of PBT2 for Huntington's disease

Dr Jeff Carroll on February 20, 2014

The results are in from the Reach2HD study, which was designed to test the experimental drug PBT2 for early and mid-stage Huntington's disease. The drug seems safe and well-tolerated at the doses that were tested, but we have major concerns about the way the results have been reported.

Does high-dose creatine "slow the onset" of Huntington's Disease?

Does high-dose creatine "slow the onset" of Huntington's Disease?

Dr Jeff Carroll on February 11, 2014

The results of a new study called PRECREST, investigating whether the nutritional supplement creatine can slow Huntington's disease progression, have just been published. Uniquely, this studied the effects of high-dose creatine supplementation in people carrying the HD mutation, but without clear disease symptoms.

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Leora Fox on February 05, 2014

Many types of stresses occur within cells that have the HD gene, and examining how simple organisms cope can help scientists define new targets for HD drugs. A new study examines yeast to determine which proteins can protect these cells from damage and death, uncovering a protective antioxidant and a related drug.

Joint HDBuzz Prizewinner: Pennies for your neurons — copper’s bad influence on Huntington’s disease

Joint HDBuzz Prizewinner: Pennies for your neurons — copper’s bad influence on Huntington’s disease

Terry Jo Bichell on January 30, 2014

Copper, the metal, may play a role in worsening the symptoms of Huntington’s disease. Bing Zhou and his team looked for connections between HD and the amount of copper in neurons. They report that reducing copper in neurons or keeping it from binding to the HD protein improves symptoms.