Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.
Huntington’s disease is caused by the accumulation of the toxic mutant huntingtin (mHTT) protein. This means that decreasing levels of mHTT, by boosting its breakdown, could be therapeutically beneficial. Palacino and colleagues have identified a possible contender for this role: negative regulator of ubiquitin-like protein 1, better known as NUB1.
Many types of stresses occur within cells that have the HD gene, and examining how simple organisms cope can help scientists define new targets for HD drugs. A new study examines yeast to determine which proteins can protect these cells from damage and death, uncovering a protective antioxidant and a related drug.
Copper, the metal, may play a role in worsening the symptoms of Huntington’s disease. Bing Zhou and his team looked for connections between HD and the amount of copper in neurons. They report that reducing copper in neurons or keeping it from binding to the HD protein improves symptoms.
We’re pleased to announce the 2013 HDBuzz Prize, an opportunity for early-career Huntington’s disease researchers to get involved in communicating HD science to the global community, see their work published here and win US$500 in Amazon vouchers!
Synapses, the connections between neurons, may turn out to be a good target for Huntington's disease therapies. Recent research has identified a new piece of the puzzle regarding synapses and HD-and a new target to aim for.
Deep brain stimulation - a procedure in which miniature electrodes that release pulses of electricity are implanted into the brain - sounds like something out of a scary science fiction movie. However, this sci-fi-like treatment may prove useful for reducing symptoms of uncontrollable movement known as chorea in patients with HD.
We're pleased to announce the HDBuzz prize, an opportunity for early-career Huntington's disease researchers to get involved in communicating HD science to the global community, see their work published here and win real human money!