Articles with the topic: cognition

The dust has settled: Sage’s dalzanemdor won’t advance for cognitive impairment

The dust has settled: Sage’s dalzanemdor won’t advance for cognitive impairment

Changes in thinking, learning, and memory are some of the most distressing and impactful in Huntington’s disease. Sage Therapeutics was advancing their drug dalzanemdor to treat these symptoms, but unfortunately this program will be halted.

Dr Sarah HernandezNovember 20, 2024

14 changes for a healthier brain

14 changes for a healthier brain

In 2019, there were ~57 million people living with dementia. By 2050, that number is expected to climb to 153 million. Changes in the 14 factors highlighted here can improve brain health and be applied to Huntington’s disease.

Dr Sarah HernandezSeptember 30, 2024

SURVEYOR opens the door for drugs that treat cognition

SURVEYOR opens the door for drugs that treat cognition

Sage Therapeutics announced results from SURVEYOR, a trial that looked at cognitive changes in people with HD, and tested short-term safety of dalzanemdor. The study was small but met key goals, and additional trials are in progress.

Dr Leora FoxJune 12, 2024

HD Young Adult Study defines the sweet spot: symptom-free with measurable changes

HD Young Adult Study defines the sweet spot: symptom-free with measurable changes

We know that HD-related changes can occur many years before symptom onset, but how early do those changes begin? A team of researchers set out to determine that with a new comprehensive study in pre-manifest HD young adults.

Dr Sarah HernandezMay 27, 2020

Thinking clearly about the earliest symptoms of HD and which brain regions control them

Thinking clearly about the earliest symptoms of HD and which brain regions control them

HD reaches more brain structures than we thought: new research broadens our understanding of the earliest signs of HD

Mr. Shawn MinnigApril 18, 2016

Through a Broader Lens: Looking at Non-Motor Symptoms in HD

Through a Broader Lens: Looking at Non-Motor Symptoms in HD

Sleep deficits precede motor problems in HD

Melissa ChristiansonJanuary 25, 2016

A multiple sclerosis drug that works for Huntington's disease: the real deal or too good to be true?

A multiple sclerosis drug that works for Huntington's disease: the real deal or too good to be true?

Fingolimod, a drug used in multiple sclerosis, prevents memory problems in HD mice. Would it work in patients?

Melissa ChristiansonNovember 24, 2015

Does high-dose creatine "slow the onset" of Huntington's Disease?

Does high-dose creatine "slow the onset" of Huntington's Disease?

A new study claims that high-dose creatine "slows the onset of Huntington Disease". How much hope and how much hype?

Dr Jeff CarrollFebruary 11, 2014

Buzzilia Video: Day 2

Buzzilia Video: Day 2

Video from day 2 of Buzzilia: nightly news, interviews and features from the HD World Congress 2013 in Brazil

Professor Ed WildOctober 19, 2013

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