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2025: Year in Review
Latest News
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Break Up With Your CAGs: How Three Letters Could Change Huntington’s Disease
Scientists engineered stem cells with “interrupted” CAG repeats to break up the toxic stretch. This may stop expansion, and could improve problems in cells that model Huntington’s disease. This study suggests that DNA spelling can drive the disease.
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Making babies: having a family, the HD way
Making babies: HDBuzz's feature article – updated for 2024 – on fertility technologies that can help at-risk people to have HD-free children
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Re-routing the huntingtin protein inside cells
Canadian team decodes the tags that re-route the huntingtin protein within cells, helping explain how it becomes toxi
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Not all in your head: digestive problems in HD
Huntington's disease mice absorb less nutrition from food – which might help explain why human patients lose weight.
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Huntexil update: EMA asks for further trial
European Medicines Agency (EMA) tells NeuroSearch a European license for Huntexil in HD requires another large trial
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KMO inhibitor drug improves lifespan of Huntington's disease mice
Positive results from tests of a new 'KMO inhibiting' drug in Huntington's disease mice
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Meet the enemy: neutron ray reveals HD protein structure
Scientists use beams of neutrons to study the structure of clumps of mutant huntingtin protein
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'Floating' gene-silencing drugs into the brain with exosomes
Exosomes – tiny bubbles made by cells – could be used to get gene silencing drugs from the bloodstream into the brain
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Improving Huntington's disease clinical trial recruitment through patient and family education
How can we improve recruitment into Huntington's disease clinical trials? Talking directly with families works!
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Chubby mice reveal the importance of the hypothalamus in Huntington's disease
Huntington's disease mice are fat but HD patients lose weight – is a brain area called the hypothalamus to blame?
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The genetic 'gray area' of Huntington's disease: what does it all mean?
Intermediate alleles and reduced penetrance – the genetic 'gray area' of Huntington’s disease, explained
