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Prilenia shares HD trial data with CHDI to help future research
Latest News
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Fund the Buzz: The $8,000 Reason HDBuzz Can Tell You the Truth
⏱️ 6 min read | HDBuzz is launching Fund the Buzz, our spring fundraising campaign! We’re independent, pharma funding-free, and run by scientists who know HD. Help us keep the lights on (and stay lawsuit-free).
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Cutting to the chase with CRISPR
⏱️ 6 min read | A new study uses “self-switching” genetic scissors to target the root cause of Huntington’s disease in mice – even after symptoms begin.
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Artificial Intelligence enters the HD space as a diagnostic tool
⏱️9 min read | From predicting symptom onset to tracking movement changes via smartwatch, artificial intelligence tools are being used in research. Here’s where we are, and why Huntington’s disease is a strong candidate for these approaches.
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Blocking a toxic fragment: new mouse study highlights the importance of HTT1a in Huntington’s disease
⏱️ 9 min read |New research in a HD mouse model points to a key culprit: a small fragment called HTT1a. Lowering HTT1a levels successfully delayed disease signs in mice that model HD, perhaps shaping the next generation of HTT-lowering therapies.
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Between Care, Genes, and Systems: Navigating Huntington’s Disease as a Caregiver
A small study based in Ireland asked a simple question: what does caring for someone with Huntington’s disease feel like? The answers point to isolation, stigma, and major gaps in healthcare support for many of the respondents.
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Your Wrist on Watch: Could a Smartwatch Reveal Huntington’s Disease Symptoms?
⏱️ 7 min read | A wrist sensor tracked arm movements in people with HD for a week and could see who had HD and who didn’t. This kind of technology could change how we measure drug effects in trials.
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March 2026: This Month in Huntington’s Disease Research
⏱️ 9 min read | March brought us the annual CHDI therapeutics conference along with updates from 3 ongoing clinical trials. We also covered new research on somatic expansion and honored the community that built our science during Gratitude Day.
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Two Heads Are Better Than One: Combined Physical and Music Therapy for Late-Stage Huntington’s Disease
A new study looking into combined music and physical therapy shows that simple rhythmic cues work better than complex music or instructions, helping to improve movement control and reducing chorea.
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A Guest Perspective for Gratitude Day: Why Huntington’s Disease May Be Neuroscience’s Best Investment
⏱️ 6 min read | Today, on Gratitude Day, we share a guest piece from HD researcher Roy Maimon that Huntington’s disease is neuroscience’s best investment, not just for its scientific clarity, but for the remarkable community built around it.
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The Girl at the End of the World: A Gratitude Day Reflection on the Place that Built Our Science
⏱️ 9 min read | This Gratitude Day, March 23rd, we celebrate the extraordinary partnership between HD families, scientists, and caregivers, and reflect on the place that built the science on which we all stand.
HDBuzz Trial Tracker
Sites for Phase 3 trial for votoplam, INVEST-HD, now open. Updates on recruitment and first dosing imminent.
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REGEN4HD, Phase 1 stem cell implantation study commences
Progress update for NCT06585449 – A Study to Evaluate ALN-HTT02
