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Picking MSH3’s Pocket: New Insights into CAG Repeat Expansion
8 min read
Latest News
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What Pigs Revealed that Mice Missed in Huntington’s Disease
9 min read
A change in one gene can disrupt thousands of others in HD. A study in pigs suggests an explanation: expanded huntingtin interferes with chemical marks on DNA. The same effect wasn’t seen in mice, showing that the animal model matters.
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Precision huntingtin-lowering drug trials target the mutant protein
10 min read
WAVE Life Sciences launches PRECISION clinical trial to suppress the mutant Huntington's disease protein
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A step forward for gene editing: CRISPR-Cas9 and HD
9 min read
Evolving CRISPR-Cas9 techniques can now be used to edit the HD gene in a living mouse brain.
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Update confirms Huntington's disease 'gene silencing' trial on track
10 min read
Ionis says its trial of HTTRx, intended to lower huntingtin protein, is fully recruited and plans to extend it
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New study reveals a potential HD biomarker
8 min read
A potential HD biomarker has been uncovered in a recent clinical study
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Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)
8 min read
Media reports of a wonder drug for neurodegenerative diseases like Huntington's disease are overhyped
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Huntington's Disease Therapeutics Conference 2017 – Day 3
5 min read
HDBuzz summarises final day of the 2017 Huntington's Disease Therapeutics Conference in Malta
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Huntington's Disease Therapeutics Conference 2017 – Day 2
4 min read
HDBuzz summarises all the science from the 2017 Huntington's Disease Therapeutics Conference in Malta – day 2
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Huntington's Disease Therapeutics Conference 2017 – Day 1
6 min read
HDBuzz summarises all the science from the 2017 Huntington's Disease Therapeutics Conference in Malta – day 1
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Enemy at the gates – huntingtin disrupts nuclear transport
7 min read
Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.
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FDA approves a new drug for symptoms of Huntington's disease
4 min read
Deutetrabenazine becomes the first new drug in a decade licensed by the FDA for symptoms of Huntington's disease
HDBuzz Trial Tracker
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
