Latest News
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Sealing the gap: a case for slower, smarter DNA repair
⏱️ 7 min read | Your body assembles DNA like a team of workers who set and bond a pattern of tiles. A recent study shows that one special assistant might slow somatic CAG expansion and delaying HD onset.
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Liftoff: First humans treated with gene silencing drugs for HD!
Major Announcement: First HD patients treated with gene silencing drugs
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HDBuzz primer: Clinical trial designs and phases
HDBuzz untangles hope from hype in clinical trial announcements
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A Few Bad Seeds: Using Brain Fluid to Grow Clumps in Brain Cells
HD brain fluid makes brain cells grow clumps.
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New tool to measure outcomes in Huntington’s Disease clinical trials
A better tool for HD trials! New research shows innovative way to measure mutant Huntingtin outside the brain
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Huge study reveals new 'genetic modifiers' of Huntington's disease
GeM-HD identifies the first solid leads in the hunt for genetic variations that affect Huntington's disease onset
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Would ewe believe it? GM1, sheep and Huntington's disease
HD researchers and sheep farmers are collaborating on a brain fat called GM1, but a clinical trial is a long way off
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Switching it up: variety in the HD gene affects symptom onset
Variety in the HD gene’s on switch affects when symptoms arise.
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Measuring harmful huntingtin protein in the brain’s bath water
How will we know whether HD-lowering treatments are working? New advancements in the detection of mutant huntingtin.
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A faulty filter? Blood vessel changes in Huntington's disease
New research reveals blood vessel changes that could contribute to problem in HD
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Lighting the way: A new biomarker for Huntington’s disease
A new biomarker reveals brain changes in early Huntington's disease.
HDBuzz Trial Tracker
Sites for Phase 3 trial for votoplam, INVEST-HD, now open. Updates on recruitment and first dosing imminent.
REGEN4HD, Phase 1 stem cell implantation study commences
Progress update for NCT06585449 – A Study to Evaluate ALN-HTT02
Updates from the ongoing placebo-controlled Phase 2/3 FALCON-HD trial
Previously featured
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Sealing the gap: a case for slower, smarter DNA repair
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HDBuzz 2025 Annual Report: Here’s what you made possible
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Skyhawk reports encouraging 12-month results for oral Huntington’s disease drug SKY-0515
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May 2026: This Month in Huntington’s Disease Research
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Fixing the Recipe: Lowering a Slice of Huntingtin
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