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May 2025: This Month in Huntingtonās Disease Research
Latest News
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Mind Your Mouth: Huntingtonās Disease and Oral Health
A recently published review discusses the challenges of dental care for people with HD, and the ways that informed dentists and medical teams can help to manage oral healthcare throughout the HD journey.
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Updates from uniQure about their gene therapy for Huntington's disease
uniQure is conducting safety trials of the first gene therapy for HD. A recent press release provided a 1 year update on the first group of 10 people who underwent surgery to receive this experimental drug. Letās talk more about what it means.
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Artificial intelligence to save the day? How clever computers are helping us understand Huntingtonās disease.
Scientists at IBM and the CHDI Foundation have used artificial intelligence to analyse datasets from Huntingtonās disease observational trials to model progression of the disease. They hope their findings will help improve clinical trial design.
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A new roadmap to track Huntingtonās disease progression
Researchers have updated the system that classifies Huntingtonās disease progression. Tracking progression in 4 stages will make clinical trial screening and data interpretation easier and faster, and pave the way for pre-symptomatic trials.
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Revisiting vitamin therapy for HD
A small clinical trial of high-dose biotin and thiamine for treating HD is being planned in Spain. This trial is based on research that links HD to another neurodegenerative disease called biotin-thiamine responsive basal ganglia disease (BTBGD).
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A spoonful of branaplam helps the huntingtin go down
Branaplam was originally designed to treat spinal muscular atrophy, but a new paper outlines how it could hold promise for treating Huntingtonās. This oral drug lowers huntingtin protein and will now be tested in a study called VIBRANT-HD.
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Huntingtonās disease therapeutics conference 2022 – Day 3
Check out research updates from Day 3 of the 2022 HD Therapeutics Conference #HDTC2022
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Huntingtonās disease therapeutics conference 2022 – Day 1
Check out research updates from Day 1 of the 2022 HD Therapeutics Conference #HDTC2022
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Huntingtonās disease therapeutics conference 2022 – Day 2
Check out research updates from Day 2 of the 2022 HD Therapeutics Conference #HDTC2022
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Shining a spotlight on huntingtin: a tool to measure huntingtin-lowering in real time
A new imaging tool means that scientists can now directly measure the levels of the toxic huntingtin protein in animal models of Huntingtonās disease, letting us see how well huntingtin lowering therapies are working in their brains
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BAC to basics: a more accurate mouse model for Huntington's disease
A genetically-tweaked Huntington's disease mouse model shows a tendency for the CAG repeat to grow, just like we see in humans with the mutation.