HDAC inhibitor drug protects memory in HD mice

HDAC inhibitor drug protects memory in HD mice

CBP, a gene-switching protein, protects memory in HD mice; 'histone deacetylase inhibitor' drug mimics its effects

Professor Ed WildDecember 13, 2011

Turning down the volume with dantrolene helps HD mice

Turning down the volume with dantrolene helps HD mice

Dantrolene, an muscle-relaxer drug already on the market, helps HD mice by reducing cellular calcium levels

Dr Jeff CarrollDecember 08, 2011

TRACK-HD reveals changes in HD mutation carriers, empowering future trials

TRACK-HD reveals changes in HD mutation carriers, empowering future trials

Follow-up data from TRACK-HD study proves that we have the tests we need to successfully run drug trials for HD

Prof Anne RosserDecember 05, 2011

Huntexil hits the headlines again

Huntexil hits the headlines again

Huntexil makes headlines with science journal article, but nothing's changed: another trial is needed before approval

Professor Ed WildNovember 22, 2011

New antibody reveals dangerous parts of huntingtin protein

New antibody reveals dangerous parts of huntingtin protein

A new antibody lets scientists identify neurons that are going to die after producing mutant huntingtin

Dr Jeff CarrollNovember 17, 2011

Safety trials add crucial piece to gene silencing jigsaw

Safety trials add crucial piece to gene silencing jigsaw

Three trials of drugs to 'silence' the HD gene in monkeys show they hit the target safely. Human trials coming soon.

Professor Ed WildNovember 14, 2011

Melatonin treatment success in HD mice

Melatonin treatment success in HD mice

Melatonin delays disease onset and extends survival in Huntington's disease mice – could it do the same for patients?

Professor Ed WildOctober 31, 2011

HD World Congress 2011: a retrospective

HD World Congress 2011: a retrospective

HDBuzz looks back at the highlights of the Huntington's disease world congress 2011 in Melbourne

Dr Jeff CarrollOctober 24, 2011

HDAC inhibitors and a possible 'blood biomarker'

HDAC inhibitors and a possible 'blood biomarker'

HDAC inhibitors explained, plus how new HDAC-related Huntington's disease research might help us find biomarkers

Professor Ed WildOctober 14, 2011

HD just got cilia

HD just got cilia

Huntington's disease just got cilia: huntingtin protein affects tiny but important hairs on cells called cilia

Dr Jeff CarrollOctober 11, 2011

Gene silencing takes a targeted step forward

Gene silencing takes a targeted step forward

Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched

Dr Michael OrthOctober 07, 2011

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