Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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FDA: further trial needed for Huntexil approval in HD

FDA: further trial needed for Huntexil approval in HD

Dr Jeff Carroll on April 04, 2011

NeuroSearch, the developer of experimental Huntington's disease drug Huntexil, has reported on their meeting with the FDA. The FDA requires that another trial be conducted before Huntexil could be approved in the US.

Successful gene therapy trial in Parkinson’s Disease gives hope for HD

Successful gene therapy trial in Parkinson’s Disease gives hope for HD

Dr Jeff Carroll on March 31, 2011

Scientists have successfully used viruses to deliver genes to the brains of Parkinson’s Disease patients. The gene carried by the viruses improved the movement symptoms of patients receiving injections. This proves that gene therapy in the brain can work, providing hope for similar therapies in HD.

Gene silencing for HD: the story so far

Gene silencing for HD: the story so far

Dr Ed Wild on March 22, 2011

Gene silencing means using specially designed molecules to 'switch off' the message that makes cells produce the harmful huntingtin protein. Our HDBuzz gene silencing primer explains the techniques, results so far and the challenges ahead.

Interview: Graeme Bilbe, Global Head for Neuroscience at Novartis

Interview: Graeme Bilbe, Global Head for Neuroscience at Novartis

Dr Ed Wild on March 14, 2011

One of the world’s largest pharmaceutical companies, Novartis, has been working on treatments for HD for the last five years. HDBuzz interviewed Graeme Bilbe, Global Head for Neuroscience at Novartis, to find out more about their progress.

What do sheep brains have to do with HD?

What do sheep brains have to do with HD?

Dr Jeff Carroll on March 09, 2011

A leading HD researcher is studying how well sheep adapt to change. Believe it or not, this work could be important for the development of cutting-edge treatments for HD.

Interview: CHDI Management

Interview: CHDI Management

Dr Jeff Carroll on February 25, 2011

CHDI Foundation, Inc. is a unique drug discovery organization focused exclusively on rapidly developing therapies that slow the progression of HD. It is the biggest funder and organizer of HD research worldwide, but many people affected by HD have never heard of it. During CHDI’s Annual Therapeutics Conference in Palm Springs, HDBuzz spoke exclusively to three of its scientific leaders.

CHDI Report: Day 3

CHDI Report: Day 3

Dr Jeff Carroll on February 10, 2011

Our third and final daily report from CHDI’s annual HD therapies meeting in Palm Springs, covering chemicals that can help neurons to survive, and insights into CHDI’s most advanced experimental drug programs.

CHDI Report: Day 2

CHDI Report: Day 2

Dr Ed Wild on February 09, 2011

Our second daily report from CHDI’s annual HD therapies meeting in Palm Springs, devoted to problems with energy generation and chemical pathways … and ways we might be able to fix them

CHDI Report: Day 1

CHDI Report: Day 1

Dr Jeff Carroll on February 08, 2011

In the first of our daily reports from CHDI’s annual HD therapies meeting in Palm Springs, we report on strategies to turn off the harmful gene and get brain cells communicating more effectively.