Re-routing the huntingtin protein inside cells

Re-routing the huntingtin protein inside cells

Canadian team decodes the tags that re-route the huntingtin protein within cells, helping explain how it becomes toxi

Dr Jeff CarrollJune 26, 2011

Not all in your head: digestive problems in HD

Not all in your head: digestive problems in HD

Huntington's disease mice absorb less nutrition from food - which might help explain why human patients lose weight.

Dr Jeff CarrollJune 18, 2011

Huntexil update: EMA asks for further trial

Huntexil update: EMA asks for further trial

European Medicines Agency (EMA) tells NeuroSearch a European license for Huntexil in HD requires another large trial

Dr Ed WildJune 06, 2011

KMO inhibitor drug improves lifespan of Huntington's disease mice

KMO inhibitor drug improves lifespan of Huntington's disease mice

Positive results from tests of a new 'KMO inhibiting' drug in Huntington's disease mice

Dr Ed WildJune 02, 2011

Meet the enemy: neutron ray reveals HD protein structure

Meet the enemy: neutron ray reveals HD protein structure

Scientists use beams of neutrons to study the structure of clumps of mutant huntingtin protein

Dr Jeff CarrollMay 26, 2011

'Floating' gene-silencing drugs into the brain with exosomes

'Floating' gene-silencing drugs into the brain with exosomes

Exosomes – tiny bubbles made by cells – could be used to get gene silencing drugs from the bloodstream into the brain

Dr Ed WildMay 19, 2011

Improving Huntington's disease clinical trial recruitment through patient and family education

Improving Huntington's disease clinical trial recruitment through patient and family education

How can we improve recruitment into Huntington's disease clinical trials? Talking directly with families works!

Dr Jeff CarrollMay 12, 2011

Chubby mice reveal the importance of the hypothalamus in Huntington's disease

Chubby mice reveal the importance of the hypothalamus in Huntington's disease

Huntington's disease mice are fat but HD patients lose weight – is a brain area called the hypothalamus to blame?

Dr Ed WildMay 02, 2011

The genetic 'gray area' of Huntington's disease: what does it all mean?

The genetic 'gray area' of Huntington's disease: what does it all mean?

Intermediate alleles and reduced penetrance – the genetic 'gray area' of Huntington’s disease, explained

Dr Nayana LahiriApril 22, 2011

Dimebon fails in late-stage human HD clinical trial

Dimebon fails in late-stage human HD clinical trial

Dimebon fails to improve symptoms in HD patients in the HORIZON trial

Dr Jeff CarrollApril 11, 2011

FDA: further trial needed for Huntexil approval in HD

FDA: further trial needed for Huntexil approval in HD

Bad news for Huntexil – the FDA requires another trial before it can be approved in the US

Dr Jeff CarrollApril 04, 2011