Latest news

When genes are unstable: targeting somatic instability in HD

When genes are unstable: targeting somatic instability in HD

CAG repeats expand in some parts of the body and brain as people with HD get older, a phenomenon known as somatic instability. Learn more about how researchers are exploring somatic instability and DNA repair to design therapies for HD.

Dr Rachel Harding and Dr Leora FoxSeptember 08, 2020

Working as a team: Changes in brain development mean some brain regions may be slacking off

Working as a team: Changes in brain development mean some brain regions may be slacking off

Scientists use human fetal tissue to look at HD brain development. But what do developmental changes mean when symptoms don’t occur until decades after birth?

Dr Sarah HernandezAugust 17, 2020

Caution urged for the use of gene-editing technology CRISPR

Caution urged for the use of gene-editing technology CRISPR

A recent series of studies on the gene-editing method CRISPR have raised concerns about the suitability of this technology for the treatment of genetic illnesses such as Huntington's disease

Dr Rachel HardingAugust 12, 2020

HD and Histamines: Targeting Hybrid Receptors to Quiet Stressful Brain Talk

HD and Histamines: Targeting Hybrid Receptors to Quiet Stressful Brain Talk

Scientists recently used an antihistamine to quiet dopamine messages in the brain and treat HD-like symptoms in mice. But beware the hype suggesting that allergy medicines could be used to slow down HD.

Dr Leora FoxJuly 15, 2020

Changing jobs: converting other cell types into neurons

Changing jobs: converting other cell types into neurons

Because HD causes a loss of neurons in the brain, some researchers are exploring ways to replace them. Working with HD mice, scientists recently showed that supportive brain cells called glia can be coaxed into becoming new neurons.

Dr Sarah HernandezJune 23, 2020

HD Young Adult Study defines the sweet spot: symptom-free with measurable changes

HD Young Adult Study defines the sweet spot: symptom-free with measurable changes

We know that HD-related changes can occur many years before symptom onset, but how early do those changes begin? A team of researchers set out to determine that with a new comprehensive study in pre-manifest HD young adults.

Dr Sarah HernandezMay 27, 2020

Fountain of youth: HTT protein repairs neurons by maintaining youthful state

Fountain of youth: HTT protein repairs neurons by maintaining youthful state

Another clue about the normal function of the huntingtin protein; a team of scientists has recently found that huntingtin seems to play an important role in repairing damaged nerve cells

Dr Rachel Harding and Dr Sarah HernandezMay 13, 2020

What does COVID-19 mean for Huntington’s disease families and HD research?

What does COVID-19 mean for Huntington’s disease families and HD research?

COVID-19 update: what does it mean for HD families, how does it impact HD research, and how has it changed the way science works?

Dr Sarah Hernandez and Dr Ed WildApril 06, 2020

New molecule can reverse the Huntington's disease mutation in lab models

New molecule can reverse the Huntington's disease mutation in lab models

A collaborative team of scientists from Canada and Japan have identified a small molecule which can change the CAG-repeat length in different lab models of Huntington's disease. #HuntingtonsDisease #DrugDiscovery

Dr Michael FlowerApril 06, 2020

Huntington’s disease therapeutics conference 2020 - Day 1

Huntington’s disease therapeutics conference 2020 - Day 1

HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs

Dr Rachel Harding, Dr Sarah Hernandez, and Joel StantonMarch 12, 2020

Huntington’s disease therapeutics conference 2020 - Day 3

Huntington’s disease therapeutics conference 2020 - Day 3

HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs

Dr Sarah Hernandez, Dr Rachel Harding, and Joel StantonMarch 03, 2020