stem-cells
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Replacing What Is Lost: Regrowing Damaged Brain Cells for Huntington’s Disease
Cell replacement therapy is making massive strides for other diseases. But what about Huntington’s disease? Can we use technological advancements in this area to replace lost brain cells with the hope of repairing and reversing disease?
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Mini brains grown in a dish shed light on Huntington’s disease and how we might treat it
Exciting new findings using 3D human lab-grown mini brains inform ongoing HTT-lowering trials and suggest that stem cell transplants for HD may improve cell-to-cell communication and reduce disease features.
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The VIP section: velvet ropes for the brain and how to get in
New work from two groups advances tools to model the blood-brain barrier and could improve the way drugs are delivered for brain diseases. This builds on our ability to study, and eventually treat, Huntington’s disease.
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Youthful competitors: young brain cells oust the old
Replacing cells with HD in the brain could be an effective treatment strategy. Recent work shows that glia injected into mouse brains take over and oust the older cells, but for a surprising reason – because of age, not HD!
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The third dimension: using minibrains to understand brain development changes in HD
Researchers show that highly expanded CAGs in the HD gene can cause early developmental changes using 3D brain models called organoids. What’d they find?
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Huntington's disease therapeutics conference 2018 – day 1
Our daily roundup of the science presented at the 2018 HD Therapeutics Conference in Palm Springs
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Huntington's Disease Therapeutics Conference 2017 – Day 3
HDBuzz summarises final day of the 2017 Huntington's Disease Therapeutics Conference in Malta
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Huntington's Disease Therapeutics Conference 2016 – day 3
Stem cells and modeling Huntington's disease in our final Therapeutics Conference report
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Turning skin cells into brain cells: a Huntington's disease research breakthrough?
Scientists can now change human skin cells into working neurons, like the ones that are most affected in HD.
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Jumping genes: Huntington's disease protein invades brain transplants
A long-term study of the brains of HD patients who received grafts of fetal tissue reveals a surprising result