gene-silencing
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Mutant yeast highlights crucial CAG-reading protein
5 min read
A new job for a DNA-reading protein called SPT4 – controlling the balance of mutant and healthy huntingtin protein
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HD Therapeutics Conference 2012 Updates: Day 2
4 min read
Day 2 of our coverage of the Huntington's Disease Therapeutics Conference
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Double success for huntingtin RNAi gene silencing
9 min read
2 bits of good news for RNAi gene silencing in HD: it's safe over six months, and a way to treat bigger brain areas
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Safety trials add crucial piece to gene silencing jigsaw
10 min read
Three trials of drugs to 'silence' the HD gene in monkeys show they hit the target safely. Human trials coming soon.
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HD just got cilia
5 min read
Huntington's disease just got cilia: huntingtin protein affects tiny but important hairs on cells called cilia
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Gene silencing takes a targeted step forward
6 min read
Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched
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A back-to-front hidden message in the HD gene?
7 min read
Unzip your genes! A backwards message, hidden in the 'backup DNA' of the Huntington's disease gene… what does it me
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Cut-and-paste DNA: fixing mutations with 'genome editing'
7 min read
Scientists make precise changes to the DNA of a live animal. Could it work for human genetic diseases?
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'Floating' gene-silencing drugs into the brain with exosomes
6 min read
Exosomes – tiny bubbles made by cells – could be used to get gene silencing drugs from the bloodstream into the brain
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Gene silencing for HD: the story so far
10 min read
Is gene silencing as exciting as it sounds for HD, and what might the future hold?