gene-silencing
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Mutant yeast highlights crucial CAG-reading protein
A new job for a DNA-reading protein called SPT4 – controlling the balance of mutant and healthy huntingtin protein
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HD Therapeutics Conference 2012 Updates: Day 2
Day 2 of our coverage of the Huntington's Disease Therapeutics Conference
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Safety trials add crucial piece to gene silencing jigsaw
Three trials of drugs to 'silence' the HD gene in monkeys show they hit the target safely. Human trials coming soon.
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HD just got cilia
Huntington's disease just got cilia: huntingtin protein affects tiny but important hairs on cells called cilia
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A back-to-front hidden message in the HD gene?
Unzip your genes! A backwards message, hidden in the 'backup DNA' of the Huntington's disease gene… what does it me
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Cut-and-paste DNA: fixing mutations with 'genome editing'
Scientists make precise changes to the DNA of a live animal. Could it work for human genetic diseases?
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'Floating' gene-silencing drugs into the brain with exosomes
Exosomes – tiny bubbles made by cells – could be used to get gene silencing drugs from the bloodstream into the brain